年龄和毛发皮质醇水平是 SARS-CoV-2 感染的预测因素

3区 综合性期刊 Q1 Medicine
Nancy Fiedler, Pamela Ohman-Strickland, Jialin Doris Shen, Kathleen Black, Daniel B. Horton, Reynold Panettieri, Martin J. Blaser, Jeffrey Carson, Kestutis Bendinskas, Hana Cheng, Emily S. Barrett
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引用次数: 0

摘要

众所周知,长期的社会心理压力会对免疫功能产生不利影响。在SARS-CoV-2大流行期间,由于感染风险和工作要求,医疗工作者的职业压力达到了前所未有的水平。我们进行了一项巢式病例对照研究,以调查慢性压力与感染 SARS-CoV-2 风险之间的关系。我们从一家学术医疗中心的员工中采集了 3 厘米长的头发,这些员工的 SARS-CoV-2 检测结果呈阳性(49 人),对照组的检测结果呈阴性(49 人),他们的年龄、种族和性别均匹配。SARS-CoV-2 的诊断依据是聚合酶链反应或抗体检测。作为慢性压力的替代指标,我们将头发切成 1 厘米长的小段,每段代表一个月,并使用皮质醇酶联免疫吸附测定法测量皮质醇水平。对于病例,我们使用 SARS-CoV-2 检测呈阳性前一个月的毛发片段测量皮质醇浓度;对于对照组,我们使用时间匹配的毛发片段测量皮质醇浓度。我们建立了条件逻辑回归模型,对性别、年龄、种族、体重指数和医护人员状况进行了调整,并按年龄较大与较小(截止年龄 = 41 岁)进行了分层。与其他种族和族裔的参与者相比,非裔美国人的毛发皮质醇水平较高。在调整模型中,在年龄较大而非较小的参与者中,毛发皮质醇浓度较高与感染 SARS-CoV-2 的几率增加有关(OR = 1.84;CI:1.10-3.07)。研究结果表明,社会心理压力可能是感染 SARS-CoV-2 的风险因素;压力管理可能是预防 SARS-CoV-2 感染的综合方法的重要组成部分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Age and Hair Cortisol Levels as Predictors of SARS-CoV-2 Infection
Chronic psychosocial stress is known to adversely impact immune function. During the SARS-CoV-2 pandemic, occupational stress among workers in healthcare was at an unprecedented level due to risks of infection and work demands. We performed a nested case–control study to investigate the associations between chronic stress and the risks of contracting SARS-CoV-2. We collected 3 cm of hair from employees at an academic medical center who tested positive for SARS-CoV-2 (N = 49) and controls who tested negative (N = 49), matched for age, race, and sex. The diagnosis of SARS-CoV-2 was based on polymerase chain reaction or antibody tests. As a proxy for chronic stress, we segmented hair into 1 cm sections each representing one month and measured cortisol levels using a cortisol enzyme-linked immunosorbent assay. For cases, we used cortisol concentrations measured in hair segments from the month prior to a positive SARS-CoV-2 test, and for controls, we used time-matched hair segments. We fitted conditional logistic regression models adjusted for sex, age, race, body mass index, and healthcare worker status, and stratified models by older vs. younger age (cutoff = 41 years). African Americans had higher hair cortisol levels relative to participants of other races and ethnicities. In adjusted models, higher hair cortisol concentrations were associated with an increased odds of infection with SARS-CoV-2 (OR = 1.84; CI: 1.10–3.07) among older, but not younger, participants. The results suggest that psychosocial stress may be a risk factor for SARS-CoV-2 infection; stress management may be an important part of a comprehensive approach to protect against SARS-CoV-2 infection.
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来源期刊
International Journal of Environmental Research and Public Health
International Journal of Environmental Research and Public Health Medicine-Public Health, Environmental and Occupational Health
CiteScore
7.30
自引率
0.00%
发文量
14422
审稿时长
1 months
期刊介绍: International Journal of Environmental Research and Public Health (IJERPH) (ISSN 1660-4601) is a peer-reviewed scientific journal that publishes original articles, critical reviews, research notes, and short communications in the interdisciplinary area of environmental health sciences and public health. It links several scientific disciplines including biology, biochemistry, biotechnology, cellular and molecular biology, chemistry, computer science, ecology, engineering, epidemiology, genetics, immunology, microbiology, oncology, pathology, pharmacology, and toxicology, in an integrated fashion, to address critical issues related to environmental quality and public health. Therefore, IJERPH focuses on the publication of scientific and technical information on the impacts of natural phenomena and anthropogenic factors on the quality of our environment, the interrelationships between environmental health and the quality of life, as well as the socio-cultural, political, economic, and legal considerations related to environmental stewardship and public health. The 2018 IJERPH Outstanding Reviewer Award has been launched! This award acknowledge those who have generously dedicated their time to review manuscripts submitted to IJERPH. See full details at http://www.mdpi.com/journal/ijerph/awards.
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