表达血管活性肠肽的中间神经元调节行为状态对大脑皮层活动的影响

IF 4.2 3区 医学 Q2 NEUROSCIENCES
Ehsan Sabri, Renata Batista-Brito
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引用次数: 0

摘要

动物生活在复杂多变的环境中,有着不同程度的行为需求。行为状态会影响大脑皮层神经元的活动和神经元群的动态,但人们对不同行为状态下神经元活动调控背后的大脑皮层回路知之甚少。在这里,我们发现一类表达血管活性肠肽(VIP)的GABA能抑制性中间神经元,即VIP中间神经元,在小鼠面部运动所反映的行为状态调节大脑皮层活动的回路中起着关键作用。我们的研究表明,抑制 VIP 中间神经元会降低动物行为状态与单个神经元尖峰之间的相关活动。我们还发现,在安静状态下抑制 VIP 会降低神经元的同步尖峰突触,但会增加三角波功率和尖峰突触与三角波段活动的相位锁定。总之,我们的数据表明,VIP 神经元在不同时间尺度上调节大脑皮层活动的行为状态依赖性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vasoactive intestinal peptide-expressing interneurons modulate the effect of behavioral state on cortical activity
Animals live in a complex and changing environment with various degrees of behavioral demands. Behavioral states affect the activity of cortical neurons and the dynamics of neuronal populations, however not much is known about the cortical circuitry behind the modulation of neuronal activity across behavioral states. Here we show that a class of GABAergic inhibitory interneurons that express vasoactive intestinal peptide-expressing interneurons (VIP), namely VIP interneurons, play a key role in the circuits involved in the modulation of cortical activity by behavioral state, as reflected in the mice facial motion. We show that inhibition of VIP interneurons reduces the correlated activity between the behavioral state of the animal and the spiking of individual neurons. We also show that VIP inhibition during the quiet state decreases the synchronous spiking of the neurons but increases delta power and phase locking of spiking to the delta-band activity. Taken together our data show that VIP interneurons modulate the behavioral state-dependency of cortical activity across different time scales.
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来源期刊
CiteScore
7.90
自引率
3.80%
发文量
627
审稿时长
6-12 weeks
期刊介绍: Frontiers in Cellular Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the cellular mechanisms underlying cell function in the nervous system across all species. Specialty Chief Editors Egidio D‘Angelo at the University of Pavia and Christian Hansel at the University of Chicago are supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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