{"title":"揭示太空飞行引发的帕金森病样变化","authors":"Nilufar Ali, Afshin Beheshti, Greg Hampikian","doi":"arxiv-2408.15021","DOIUrl":null,"url":null,"abstract":"A meta-analysis of spaceflight data from both mouse and human flights reveals\na striking overlap with Parkinson's disease (PD). Parallels include: changes in\ngait, loss of dopamine, sustained changes in the basal ganglia, loss of\ntyrosine hydroxylase in the substantia nigra, and systemic mitochondrial\ndysfunction. We identified specific Parkinson's genes differentially expressed\npost-spaceflight. These evidences indicate that spaceflight stressor-induced\nchanges in the brain may become permanent during deep space exploration, posing\na risk of PD in astronauts","PeriodicalId":501219,"journal":{"name":"arXiv - QuanBio - Other Quantitative Biology","volume":"51 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Unveiling Parkinson's Disease-like Changes Triggered by Spaceflight\",\"authors\":\"Nilufar Ali, Afshin Beheshti, Greg Hampikian\",\"doi\":\"arxiv-2408.15021\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A meta-analysis of spaceflight data from both mouse and human flights reveals\\na striking overlap with Parkinson's disease (PD). Parallels include: changes in\\ngait, loss of dopamine, sustained changes in the basal ganglia, loss of\\ntyrosine hydroxylase in the substantia nigra, and systemic mitochondrial\\ndysfunction. We identified specific Parkinson's genes differentially expressed\\npost-spaceflight. These evidences indicate that spaceflight stressor-induced\\nchanges in the brain may become permanent during deep space exploration, posing\\na risk of PD in astronauts\",\"PeriodicalId\":501219,\"journal\":{\"name\":\"arXiv - QuanBio - Other Quantitative Biology\",\"volume\":\"51 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-08-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"arXiv - QuanBio - Other Quantitative Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/arxiv-2408.15021\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"arXiv - QuanBio - Other Quantitative Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/arxiv-2408.15021","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Unveiling Parkinson's Disease-like Changes Triggered by Spaceflight
A meta-analysis of spaceflight data from both mouse and human flights reveals
a striking overlap with Parkinson's disease (PD). Parallels include: changes in
gait, loss of dopamine, sustained changes in the basal ganglia, loss of
tyrosine hydroxylase in the substantia nigra, and systemic mitochondrial
dysfunction. We identified specific Parkinson's genes differentially expressed
post-spaceflight. These evidences indicate that spaceflight stressor-induced
changes in the brain may become permanent during deep space exploration, posing
a risk of PD in astronauts
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