Naina Kumar, Labanyamoy Kole, K. N. Deepthi, Seetesh Ghose, Rahul Narang
{"title":"探讨精液中抗PSA抗体对精液参数的影响：一项比较研究","authors":"Naina Kumar, Labanyamoy Kole, K. N. Deepthi, Seetesh Ghose, Rahul Narang","doi":"10.1071/rd24002","DOIUrl":null,"url":null,"abstract":"<strong> Context</strong><p>Prostate-specific antigen (PSA) is important for semen liquefaction and sperm motility. Anti-PSA antibodies may lead to immune infertility.</p><strong> Aims</strong><p>The present study was conducted to evaluate the impact of seminal anti-PSA antibodies on semen parameters in fertile and infertile men.</p><strong> Methods</strong><p>A cross-sectional analytic study was conducted on 105 fertile men (≥21–50 years) having biological children (within last 2 years) with normal semen analysis as controls and 105 infertile men with abnormal semen analysis as cases. All semen samples were cryopreserved till 210 samples were collected, followed by estimation of anti-PSA antibodies using an indirect enzyme-linked immunosorbent assay technique.</p><strong> Key results</strong><p>Mean ± standard deviation (s.d.) age of 210 participants was 30.0 ± 4.65 years. Mean ± s.d. levels of seminal anti-PSA antibodies in infertile men were 27.82 ± 102.19 ng/mL and in fertile men −30.45 ± 49.49 ng/mL (<i>P</i> = 0.001). A significant negative correlation was observed between anti-PSA antibody levels and sperm concentration (<i>P</i> = 0.013), rapid progressive motility (<i>P</i> = 0.001), slow progressive motility (<i>P</i> = 0.006), progressive sperm motility (<i>P</i> = 0.001), and normal morphology (<i>P</i> = 0.001), and significant positive correlation was observed with immotile sperms (<i>P</i> = 0.001). The overall accuracy of anti-PSA antibody for differentiating infertile from fertile men was 63.33%.</p><strong> Conclusions</strong><p>Seminal anti-PSA antibodies were significantly correlated with semen parameters in fertile and infertile men with an accuracy of 63.33%. A negative correlation was observed between antibody levels and progressive sperm motility.</p><strong> Implications</strong><p>Seminal anti-PSA antibodies can be used as a biomarker for male infertility assessment.</p>","PeriodicalId":20932,"journal":{"name":"Reproduction, fertility, and development","volume":"45 1","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring the impact of seminal anti-PSA antibodies on semen parameters: a comparative study\",\"authors\":\"Naina Kumar, Labanyamoy Kole, K. N. Deepthi, Seetesh Ghose, Rahul Narang\",\"doi\":\"10.1071/rd24002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<strong> Context</strong><p>Prostate-specific antigen (PSA) is important for semen liquefaction and sperm motility. Anti-PSA antibodies may lead to immune infertility.</p><strong> Aims</strong><p>The present study was conducted to evaluate the impact of seminal anti-PSA antibodies on semen parameters in fertile and infertile men.</p><strong> Methods</strong><p>A cross-sectional analytic study was conducted on 105 fertile men (≥21–50 years) having biological children (within last 2 years) with normal semen analysis as controls and 105 infertile men with abnormal semen analysis as cases. All semen samples were cryopreserved till 210 samples were collected, followed by estimation of anti-PSA antibodies using an indirect enzyme-linked immunosorbent assay technique.</p><strong> Key results</strong><p>Mean ± standard deviation (s.d.) age of 210 participants was 30.0 ± 4.65 years. Mean ± s.d. levels of seminal anti-PSA antibodies in infertile men were 27.82 ± 102.19 ng/mL and in fertile men −30.45 ± 49.49 ng/mL (<i>P</i> = 0.001). A significant negative correlation was observed between anti-PSA antibody levels and sperm concentration (<i>P</i> = 0.013), rapid progressive motility (<i>P</i> = 0.001), slow progressive motility (<i>P</i> = 0.006), progressive sperm motility (<i>P</i> = 0.001), and normal morphology (<i>P</i> = 0.001), and significant positive correlation was observed with immotile sperms (<i>P</i> = 0.001). The overall accuracy of anti-PSA antibody for differentiating infertile from fertile men was 63.33%.</p><strong> Conclusions</strong><p>Seminal anti-PSA antibodies were significantly correlated with semen parameters in fertile and infertile men with an accuracy of 63.33%. A negative correlation was observed between antibody levels and progressive sperm motility.</p><strong> Implications</strong><p>Seminal anti-PSA antibodies can be used as a biomarker for male infertility assessment.</p>\",\"PeriodicalId\":20932,\"journal\":{\"name\":\"Reproduction, fertility, and development\",\"volume\":\"45 1\",\"pages\":\"\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-09-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Reproduction, fertility, and development\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1071/rd24002\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"DEVELOPMENTAL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reproduction, fertility, and development","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1071/rd24002","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}
Exploring the impact of seminal anti-PSA antibodies on semen parameters: a comparative study
Context
Prostate-specific antigen (PSA) is important for semen liquefaction and sperm motility. Anti-PSA antibodies may lead to immune infertility.
Aims
The present study was conducted to evaluate the impact of seminal anti-PSA antibodies on semen parameters in fertile and infertile men.
Methods
A cross-sectional analytic study was conducted on 105 fertile men (≥21–50 years) having biological children (within last 2 years) with normal semen analysis as controls and 105 infertile men with abnormal semen analysis as cases. All semen samples were cryopreserved till 210 samples were collected, followed by estimation of anti-PSA antibodies using an indirect enzyme-linked immunosorbent assay technique.
Key results
Mean ± standard deviation (s.d.) age of 210 participants was 30.0 ± 4.65 years. Mean ± s.d. levels of seminal anti-PSA antibodies in infertile men were 27.82 ± 102.19 ng/mL and in fertile men −30.45 ± 49.49 ng/mL (P = 0.001). A significant negative correlation was observed between anti-PSA antibody levels and sperm concentration (P = 0.013), rapid progressive motility (P = 0.001), slow progressive motility (P = 0.006), progressive sperm motility (P = 0.001), and normal morphology (P = 0.001), and significant positive correlation was observed with immotile sperms (P = 0.001). The overall accuracy of anti-PSA antibody for differentiating infertile from fertile men was 63.33%.
Conclusions
Seminal anti-PSA antibodies were significantly correlated with semen parameters in fertile and infertile men with an accuracy of 63.33%. A negative correlation was observed between antibody levels and progressive sperm motility.
Implications
Seminal anti-PSA antibodies can be used as a biomarker for male infertility assessment.
期刊介绍：
Reproduction, Fertility and Development is an international journal for the publication of original and significant contributions on vertebrate reproductive and developmental biology. Subject areas include, but are not limited to: physiology, biochemistry, cell and molecular biology, endocrinology, genetics and epigenetics, behaviour, immunology and the development of reproductive technologies in humans, livestock and wildlife, and in pest management.
Reproduction, Fertility and Development is a valuable resource for research scientists working in industry or academia on reproductive and developmental biology, clinicians and veterinarians interested in the basic science underlying their disciplines, and students.
Reproduction, Fertility and Development is the official journal of the International Embryo Technology Society and the Society for Reproductive Biology.
Reproduction, Fertility and Development is published with the endorsement of the Commonwealth Scientific and Industrial Research Organisation (CSIRO) and the Australian Academy of Science.
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