具有综合抗菌和止血性能的阳离子淀粉微颗粒

IF 4.4 2区 工程技术 Q1 ENGINEERING, MULTIDISCIPLINARY
Yang Su, MengXin Niu, KaiDong Xu, Chen Xu, PeiLang Yang, Yang Hu, Fu-Jian Xu
{"title":"具有综合抗菌和止血性能的阳离子淀粉微颗粒","authors":"Yang Su, MengXin Niu, KaiDong Xu, Chen Xu, PeiLang Yang, Yang Hu, Fu-Jian Xu","doi":"10.1007/s11431-023-2577-7","DOIUrl":null,"url":null,"abstract":"<p>It is urgently demanded to develop biomaterials with balanced hemostatic/antibacterial ability and facile preparation methods. In this work, cationic starch microparticles (MSQP), prepared by the facile grafting of microporous starch particles (MS) with tunable quaternized polyethyleneimine, were readily constructed as promising hemostatic materials for integrated antibacterial and hemostatic performance. The cationic grafts not only endowed MSQP with good antibacterial ability, but also benefited from biocompatible MS to achieve favorable biocompatibility. Moreover, <i>in vitro</i> results confirmed the superior hemostatic property of MSQP2 (with the medium content of cationic grafts) among three MSQP and pristine MS. After investigating the blood-material interactions of MSQP/MS, the procoagulant mechanism of MSQP2 was revealed that the optimal amount of cationic grafts achieves highly balanced plasma-protein adhesion, platelet adhesion and blood coagulation system. <i>In vivo</i> artery-injury model further demonstrated the superior hemostatic performance of MSQP2 for potential severe hemorrhage. This work sheds light on the design of cationic polymer-based biomaterials for balanced antibacterial and hemostatic functions.</p>","PeriodicalId":21612,"journal":{"name":"Science China Technological Sciences","volume":"21 1","pages":""},"PeriodicalIF":4.4000,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cationic starch microparticles with integrated antibacterial and hemostatic performance\",\"authors\":\"Yang Su, MengXin Niu, KaiDong Xu, Chen Xu, PeiLang Yang, Yang Hu, Fu-Jian Xu\",\"doi\":\"10.1007/s11431-023-2577-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>It is urgently demanded to develop biomaterials with balanced hemostatic/antibacterial ability and facile preparation methods. In this work, cationic starch microparticles (MSQP), prepared by the facile grafting of microporous starch particles (MS) with tunable quaternized polyethyleneimine, were readily constructed as promising hemostatic materials for integrated antibacterial and hemostatic performance. The cationic grafts not only endowed MSQP with good antibacterial ability, but also benefited from biocompatible MS to achieve favorable biocompatibility. Moreover, <i>in vitro</i> results confirmed the superior hemostatic property of MSQP2 (with the medium content of cationic grafts) among three MSQP and pristine MS. After investigating the blood-material interactions of MSQP/MS, the procoagulant mechanism of MSQP2 was revealed that the optimal amount of cationic grafts achieves highly balanced plasma-protein adhesion, platelet adhesion and blood coagulation system. <i>In vivo</i> artery-injury model further demonstrated the superior hemostatic performance of MSQP2 for potential severe hemorrhage. This work sheds light on the design of cationic polymer-based biomaterials for balanced antibacterial and hemostatic functions.</p>\",\"PeriodicalId\":21612,\"journal\":{\"name\":\"Science China Technological Sciences\",\"volume\":\"21 1\",\"pages\":\"\"},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2024-09-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Science China Technological Sciences\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1007/s11431-023-2577-7\",\"RegionNum\":2,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science China Technological Sciences","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1007/s11431-023-2577-7","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

摘要

目前迫切需要开发止血/抗菌能力均衡、制备方法简便的生物材料。在这项研究中,阳离子淀粉微颗粒(MSQP)是通过将微孔淀粉颗粒(MS)与可调季铵化聚乙烯亚胺接枝而制备的。阳离子接枝不仅赋予了 MSQP 良好的抗菌能力,而且得益于生物相容性 MS,实现了良好的生物相容性。此外,体外实验结果证实,在三种 MSQP 和原始 MS 中,MSQP2(阳离子接枝含量适中)的止血性能更优越。在研究了 MSQP/MS 的血液-材料相互作用后,发现了 MSQP2 的促凝机制,即阳离子移植物的最佳含量可实现血浆蛋白粘附、血小板粘附和血液凝固系统的高度平衡。体内动脉损伤模型进一步证明了 MSQP2 对于潜在的严重出血具有卓越的止血性能。这项工作为设计阳离子聚合物基生物材料以实现抗菌和止血功能的平衡提供了启示。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cationic starch microparticles with integrated antibacterial and hemostatic performance

It is urgently demanded to develop biomaterials with balanced hemostatic/antibacterial ability and facile preparation methods. In this work, cationic starch microparticles (MSQP), prepared by the facile grafting of microporous starch particles (MS) with tunable quaternized polyethyleneimine, were readily constructed as promising hemostatic materials for integrated antibacterial and hemostatic performance. The cationic grafts not only endowed MSQP with good antibacterial ability, but also benefited from biocompatible MS to achieve favorable biocompatibility. Moreover, in vitro results confirmed the superior hemostatic property of MSQP2 (with the medium content of cationic grafts) among three MSQP and pristine MS. After investigating the blood-material interactions of MSQP/MS, the procoagulant mechanism of MSQP2 was revealed that the optimal amount of cationic grafts achieves highly balanced plasma-protein adhesion, platelet adhesion and blood coagulation system. In vivo artery-injury model further demonstrated the superior hemostatic performance of MSQP2 for potential severe hemorrhage. This work sheds light on the design of cationic polymer-based biomaterials for balanced antibacterial and hemostatic functions.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Science China Technological Sciences
Science China Technological Sciences ENGINEERING, MULTIDISCIPLINARY-MATERIALS SCIENCE, MULTIDISCIPLINARY
CiteScore
8.40
自引率
10.90%
发文量
4380
审稿时长
3.3 months
期刊介绍: Science China Technological Sciences, an academic journal cosponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China, and published by Science China Press, is committed to publishing high-quality, original results in both basic and applied research. Science China Technological Sciences is published in both print and electronic forms. It is indexed by Science Citation Index. Categories of articles: Reviews summarize representative results and achievements in a particular topic or an area, comment on the current state of research, and advise on the research directions. The author’s own opinion and related discussion is requested. Research papers report on important original results in all areas of technological sciences. Brief reports present short reports in a timely manner of the latest important results.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信