Olivia L Mosley, Joel A Villa, Advaitha Kamalakkannan, Eliyashaib James, Jessica M Hoffman, Yang Lyu
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引用次数: 0
摘要
膳食限制(DR)被广泛认为是延长不同物种健康寿命的最有效方法之一,但越来越明显的是,DR 介导的长寿受到生物和非生物因素的影响。我们建议,该领域目前的优先事项应包括了解这些因素的相对贡献,以阐明 DR 产生有益影响的机制。我们在两个实验室开展的工作代表了统一果蝇 DR 方案和研究 DR 随机效应的一种尝试。在 64 对生存数据(DR/自由饮食或 AL)中,我们发现 DR 并不能普遍延长寿命。具体来说,我们观察到 DR 只在 26.7%(17/64)的配对中显著延长了寿命。我们的汇总数据显示,DR 组和 AL 组之间的总体寿命差异具有统计学意义,但 DR 下寿命延长的中位数(7.1%)很小。随机因素和基因型掩盖了 DR 的影响。未来旨在全面了解 DR 依赖性机制的研究工作应侧重于揭示遗传和环境因素之间的相互作用。这对于开发延长健康寿命的个性化干预措施和优化针对个体遗传特征的饮食建议至关重要。
Stochasticity in dietary restriction-mediated lifespan outcomes in Drosophila
Dietary restriction (DR) is widely considered to be one of the most potent approaches to extend healthy lifespan across various species, yet it has become increasingly apparent that DR-mediated longevity is influenced by biological and non-biological factors. We propose that current priorities in the field should include understanding the relative contributions of these factors to elucidate the mechanisms underlying the beneficial effects of DR. Our work conducted in two laboratories, represents an attempt to unify DR protocols in Drosophila and to investigate the stochastic effects of DR. Across 64 pairs of survival data (DR/ad libitum, or AL), we find that DR does not universally extend lifespan. Specifically, we observed that DR conferred a significant lifespan extension in only 26.7% (17/64) of pairs. Our pooled data show that the overall lifespan difference between DR and AL groups is statistically significant, but the median lifespan increase under DR (7.1%) is small. The effects of DR were overshadowed by stochastic factors and genotype. Future research efforts directed toward gaining a comprehensive understanding of DR-dependent mechanisms should focus on unraveling the interactions between genetic and environmental factors. This is essential for developing personalized healthspan-extending interventions and optimizing dietary recommendations for individual genetic profiles.