具有记忆功能的可变热负荷导致活体组织中的热机械相互作用

Ibrahim A. Abbas, Abhik Sur
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引用次数: 0

摘要

为了解决活体组织内的各种临床应用问题,本研究旨在分析研究活体组织在不同热负荷下的热机械相互作用。为治疗癌症而接受区域热疗的人体组织基于细胞的分级变化,因此,其构成方程采用了非局部弹性理论。本问题的热传输方程是在摩尔-吉布森-汤普森广义热弹性理论的背景下制定的,其中吸收了滑动区间内的记忆导数。组织的两个边界都保持零牵引条件。组织的下边界承受规定的热负荷,而上边界则保持零温度。利用拉普拉斯变换机制求解了支配方程,并在变换域中获得了一般解。为了得到真实时空域中的解,使用 Zakian 方法对拉普拉斯变换进行了适当的数值反演。数值结果表明,热机械波在皮肤组织中的传播距离是有限的,这有助于减轻彭尼斯模型所做的不切实际的预测。报告指出了不同有效参数(如非局部参数和时间延迟参数)的显著影响。此外,研究还概述了非线性核函数如何在生物传热中发挥更大作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Thermomechanical interaction in a living tissue due to variable thermal loading with memory
In order to address various clinical applications within living tissue, the aim of this work is to analytically study the thermomechanical interaction for a living tissue which is subjected to variable thermal loadings. Human tissues undergoing regional hyperthermia treatment for cancer therapy is based on graded changes of the cells, and as a consequences, the constitutive equations have been formulated using the nonlocal elasticity theory. The heat transport equation for the present problem is formulated in the context of Moore‐Gibson‐Thompson theory of generalized thermoelasticity assimilating the memory‐dependent derivative within a slipping interval. Both the boundaries of the tissue is maintaining the condition of zero traction. The lower boundary of the tissue is subjected to prescribed thermal loading while, the upper boundary is kept at zero temperature. Utilizing the Laplace transform mechanism, the governing equations have been solved and the general solutions have been obtained in the transformed domain. In order to arrive at the solutions in the real space‐time domain, suitable inversion of the Laplace transform has been carried out numerically using the method of Zakian. Numerical findings suggest that thermomechanical waves propagate through skin tissue over finite distances, which helps mitigate the unrealistic predictions made by the Pennes' model. Significant effect due to different effective parameter such as nonlocal parameter and the time‐delay parameter is reported. Also, how a nonlinear kernel function can be more effective in bio‐heat transfer, is outlined in the study also.
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