众人拾柴火焰高：多层次靶向具有代表性的趋化因子和代谢物 GPCRs，实现个性化癌症治疗

IF 4.5 3区医学 Q2 IMMUNOLOGY

European Journal of Immunology Pub Date : 2024-09-12 DOI:10.1002/eji.202350870

Donato Inverso, Carlotta Tacconi, Serena Ranucci, Marco De Giovanni

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引用次数: 0

摘要

G 蛋白偶联受体（GPCRs）是重要的细胞表面受体，可调控多种生理功能。尽管它们在调节抗肿瘤免疫和肿瘤发生方面起着至关重要的作用，但目前针对 GPCR 的肿瘤学治疗应用还很有限。本综述重点研究了部分原发性趋化因子和代谢物感应 GPCR。具体来说，该综述重点介绍了能够在三个主要层面协调肿瘤免疫生物学的五种 GPCR：肿瘤免疫、癌细胞扩增和血管发育。综述最后阐明了新兴疗法，并讨论了通过应用多受体和患者特异性逻辑来充分利用 GPCR 靶向治疗潜力的创新策略。

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The power of many: Multilevel targeting of representative chemokine and metabolite GPCRs in personalized cancer therapy

G protein‐coupled receptors (GPCRs) are vital cell surface receptors that govern a myriad of physiological functions. Despite their crucial role in regulating antitumor immunity and tumorigenesis, therapeutic applications targeting GPCRs in oncology are currently limited. This review offers a focused examination of selected protumorigenic chemokine and metabolite‐sensing GPCRs. Specifically, the review highlights five GPCRs able to orchestrate tumor immunobiology at three main levels: tumor immunity, cancer cell expansion, and blood vessel development. The review culminates by illuminating emerging therapies and discussing innovative strategies to harness the full potential of GPCR‐targeted treatments, by applying a multireceptor and patient‐specific logic.

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来源期刊

European Journal of Immunology 医学-免疫学

CiteScore

8.30

自引率

3.70%

发文量

224

审稿时长

2 months

期刊介绍： The European Journal of Immunology (EJI) is an official journal of EFIS. Established in 1971, EJI continues to serve the needs of the global immunology community covering basic, translational and clinical research, ranging from adaptive and innate immunity through to vaccines and immunotherapy, cancer, autoimmunity, allergy and more. Mechanistic insights and thought-provoking immunological findings are of interest, as are studies using the latest omics technologies. We offer fast track review for competitive situations, including recently scooped papers, format free submission, transparent and fair peer review and more as detailed in our policies.