{"title":"基于磁共振成像的膝关节骨关节炎生物标志物:预测而非关联研究的叙述性综述","authors":"","doi":"10.1016/j.ejrad.2024.111731","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Magnetic Resonance Imaging (MRI) is frequently used in recent studies on knee osteoarthritis (KOA), focusing on developing innovative MRI-based biomarkers to predict KOA outcomes. The growing volume of publications devoted to this subject highlights the need for an up-to-date review.</p></div><div><h3>Methods</h3><p>In this narrative review, we utilized the PubMed database to identify studies examining MRI-based biomarkers for the prediction of knee osteoarthritis (KOA), focusing on those reporting relevant prediction, not association, metrics. The identified articles were subsequently categorized into three distinct outcomes: Prediction of KOA incidence (KOAi), KOA progression (KOAp) and total knee arthroplasty risk (TKAr). Within each category, results were organized by the nature of biomarker(s) used, as either quantitative, semi-quantitative or compound.</p></div><div><h3>Results</h3><p>Due to the lack of predictive metrics such as the area under the ROC curve (AUC) scores, sensitivity or specificity, 27 studies were excluded. A final set of 23 studies were deemed eligible for our analysis. The mean AUC scores reported ranged from 0.67 to 0.83 for predicting KOAi, 0.54 to 0.84 for KOAp and 0.55 to 0.94 for TKAr. Excellent predictive performance (AUC>0.8) was observed for the prediction of radiographic KOAi, KOAp and TKAr when using cartilage and meniscal-based measures, osteophyte scores and infrapatellar fat pad texture, and bone marrow lesions, respectively.</p></div><div><h3>Conclusion</h3><p>The results showed that numerous studies highlighted the importance of MRI-based biomarkers as promising predictors of the three key outcomes. In addition, this narrative review also emphasized the necessity for KOA prediction studies to include adequate reporting of predictive metrics.</p></div>","PeriodicalId":12063,"journal":{"name":"European Journal of Radiology","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0720048X24004479/pdfft?md5=e95ff2237a5a13663321eaf369422ff2&pid=1-s2.0-S0720048X24004479-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Magnetic resonance imaging-based biomarkers for knee osteoarthritis outcomes: A narrative review of prediction but not association studies\",\"authors\":\"\",\"doi\":\"10.1016/j.ejrad.2024.111731\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Magnetic Resonance Imaging (MRI) is frequently used in recent studies on knee osteoarthritis (KOA), focusing on developing innovative MRI-based biomarkers to predict KOA outcomes. The growing volume of publications devoted to this subject highlights the need for an up-to-date review.</p></div><div><h3>Methods</h3><p>In this narrative review, we utilized the PubMed database to identify studies examining MRI-based biomarkers for the prediction of knee osteoarthritis (KOA), focusing on those reporting relevant prediction, not association, metrics. The identified articles were subsequently categorized into three distinct outcomes: Prediction of KOA incidence (KOAi), KOA progression (KOAp) and total knee arthroplasty risk (TKAr). Within each category, results were organized by the nature of biomarker(s) used, as either quantitative, semi-quantitative or compound.</p></div><div><h3>Results</h3><p>Due to the lack of predictive metrics such as the area under the ROC curve (AUC) scores, sensitivity or specificity, 27 studies were excluded. A final set of 23 studies were deemed eligible for our analysis. The mean AUC scores reported ranged from 0.67 to 0.83 for predicting KOAi, 0.54 to 0.84 for KOAp and 0.55 to 0.94 for TKAr. Excellent predictive performance (AUC>0.8) was observed for the prediction of radiographic KOAi, KOAp and TKAr when using cartilage and meniscal-based measures, osteophyte scores and infrapatellar fat pad texture, and bone marrow lesions, respectively.</p></div><div><h3>Conclusion</h3><p>The results showed that numerous studies highlighted the importance of MRI-based biomarkers as promising predictors of the three key outcomes. In addition, this narrative review also emphasized the necessity for KOA prediction studies to include adequate reporting of predictive metrics.</p></div>\",\"PeriodicalId\":12063,\"journal\":{\"name\":\"European Journal of Radiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-09-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0720048X24004479/pdfft?md5=e95ff2237a5a13663321eaf369422ff2&pid=1-s2.0-S0720048X24004479-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Radiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0720048X24004479\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Radiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0720048X24004479","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Magnetic resonance imaging-based biomarkers for knee osteoarthritis outcomes: A narrative review of prediction but not association studies
Background
Magnetic Resonance Imaging (MRI) is frequently used in recent studies on knee osteoarthritis (KOA), focusing on developing innovative MRI-based biomarkers to predict KOA outcomes. The growing volume of publications devoted to this subject highlights the need for an up-to-date review.
Methods
In this narrative review, we utilized the PubMed database to identify studies examining MRI-based biomarkers for the prediction of knee osteoarthritis (KOA), focusing on those reporting relevant prediction, not association, metrics. The identified articles were subsequently categorized into three distinct outcomes: Prediction of KOA incidence (KOAi), KOA progression (KOAp) and total knee arthroplasty risk (TKAr). Within each category, results were organized by the nature of biomarker(s) used, as either quantitative, semi-quantitative or compound.
Results
Due to the lack of predictive metrics such as the area under the ROC curve (AUC) scores, sensitivity or specificity, 27 studies were excluded. A final set of 23 studies were deemed eligible for our analysis. The mean AUC scores reported ranged from 0.67 to 0.83 for predicting KOAi, 0.54 to 0.84 for KOAp and 0.55 to 0.94 for TKAr. Excellent predictive performance (AUC>0.8) was observed for the prediction of radiographic KOAi, KOAp and TKAr when using cartilage and meniscal-based measures, osteophyte scores and infrapatellar fat pad texture, and bone marrow lesions, respectively.
Conclusion
The results showed that numerous studies highlighted the importance of MRI-based biomarkers as promising predictors of the three key outcomes. In addition, this narrative review also emphasized the necessity for KOA prediction studies to include adequate reporting of predictive metrics.
期刊介绍:
European Journal of Radiology is an international journal which aims to communicate to its readers, state-of-the-art information on imaging developments in the form of high quality original research articles and timely reviews on current developments in the field.
Its audience includes clinicians at all levels of training including radiology trainees, newly qualified imaging specialists and the experienced radiologist. Its aim is to inform efficient, appropriate and evidence-based imaging practice to the benefit of patients worldwide.