{"title":"在拉曼光谱中利用拓扑机器学习:通过脑脊液分析检测阿尔茨海默病的前景","authors":"","doi":"10.1016/j.jfranklin.2024.107249","DOIUrl":null,"url":null,"abstract":"<div><p>The cerebrospinal fluid of 21 subjects who received a clinical diagnosis of Alzheimer’s disease (AD) as well as of 22 pathological controls has been collected and analysed by Raman spectroscopy (RS). We investigated whether the Raman spectra could be used to distinguish AD from controls, after a preprocessing procedure. We applied machine learning to a set of topological descriptors extracted from the spectra, achieving a high classification accuracy of 86%. Our experimentation indicates that RS and topological analysis may be a reliable and effective combination to confirm or disprove a clinical diagnosis of Alzheimer’s disease. The following steps will aim at leveraging the intrinsic interpretability of the topological data analysis to characterize the AD subtypes, e.g. by identifying the bands of the Raman spectrum relevant for AD detection, possibly increasing and/or confirming the knowledge about the precise molecular events and biological pathways behind the Alzheimer’s disease.</p></div>","PeriodicalId":17283,"journal":{"name":"Journal of The Franklin Institute-engineering and Applied Mathematics","volume":null,"pages":null},"PeriodicalIF":3.7000,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0016003224006707/pdfft?md5=0c005e25e9077747b7e71e8f934493b5&pid=1-s2.0-S0016003224006707-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Harnessing topological machine learning in Raman spectroscopy: Perspectives for Alzheimer’s disease detection via cerebrospinal fluid analysis\",\"authors\":\"\",\"doi\":\"10.1016/j.jfranklin.2024.107249\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The cerebrospinal fluid of 21 subjects who received a clinical diagnosis of Alzheimer’s disease (AD) as well as of 22 pathological controls has been collected and analysed by Raman spectroscopy (RS). We investigated whether the Raman spectra could be used to distinguish AD from controls, after a preprocessing procedure. We applied machine learning to a set of topological descriptors extracted from the spectra, achieving a high classification accuracy of 86%. Our experimentation indicates that RS and topological analysis may be a reliable and effective combination to confirm or disprove a clinical diagnosis of Alzheimer’s disease. The following steps will aim at leveraging the intrinsic interpretability of the topological data analysis to characterize the AD subtypes, e.g. by identifying the bands of the Raman spectrum relevant for AD detection, possibly increasing and/or confirming the knowledge about the precise molecular events and biological pathways behind the Alzheimer’s disease.</p></div>\",\"PeriodicalId\":17283,\"journal\":{\"name\":\"Journal of The Franklin Institute-engineering and Applied Mathematics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-09-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0016003224006707/pdfft?md5=0c005e25e9077747b7e71e8f934493b5&pid=1-s2.0-S0016003224006707-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of The Franklin Institute-engineering and Applied Mathematics\",\"FirstCategoryId\":\"94\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0016003224006707\",\"RegionNum\":3,\"RegionCategory\":\"计算机科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"AUTOMATION & CONTROL SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of The Franklin Institute-engineering and Applied Mathematics","FirstCategoryId":"94","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0016003224006707","RegionNum":3,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"AUTOMATION & CONTROL SYSTEMS","Score":null,"Total":0}
Harnessing topological machine learning in Raman spectroscopy: Perspectives for Alzheimer’s disease detection via cerebrospinal fluid analysis
The cerebrospinal fluid of 21 subjects who received a clinical diagnosis of Alzheimer’s disease (AD) as well as of 22 pathological controls has been collected and analysed by Raman spectroscopy (RS). We investigated whether the Raman spectra could be used to distinguish AD from controls, after a preprocessing procedure. We applied machine learning to a set of topological descriptors extracted from the spectra, achieving a high classification accuracy of 86%. Our experimentation indicates that RS and topological analysis may be a reliable and effective combination to confirm or disprove a clinical diagnosis of Alzheimer’s disease. The following steps will aim at leveraging the intrinsic interpretability of the topological data analysis to characterize the AD subtypes, e.g. by identifying the bands of the Raman spectrum relevant for AD detection, possibly increasing and/or confirming the knowledge about the precise molecular events and biological pathways behind the Alzheimer’s disease.
期刊介绍:
The Journal of The Franklin Institute has an established reputation for publishing high-quality papers in the field of engineering and applied mathematics. Its current focus is on control systems, complex networks and dynamic systems, signal processing and communications and their applications. All submitted papers are peer-reviewed. The Journal will publish original research papers and research review papers of substance. Papers and special focus issues are judged upon possible lasting value, which has been and continues to be the strength of the Journal of The Franklin Institute.