用于骨骼再生的具有分层孔隙结构的钽颗粒 多孔钽颗粒可修复骨骼

IF 6.2 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
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引用次数: 0

摘要

钽(Ta)具有优异的耐腐蚀性和生物相容性,因此在骨组织工程方面具有良好的潜力。然而,由于钽的高熔点和高硬度,为不规则形状的骨缺损定制骨修复材料一直是一项挑战。在这项研究中,受自然界砂流现象的启发,首次开发了用于修复不规则形状骨缺损的多孔钽颗粒(PTaG)。PTaG 被设计成分层多孔结构,以调节机械性能,并为细胞和组织的向内生长提供有利空间。以商用多孔钛颗粒(PTiG)和 Bio-Oss 为阳性对照,探索 PTaG 作为骨替代品的潜力。通过扫描电镜、X 射线三维成像系统、三维激光共聚焦显微镜、EDS、XRD、XPS 和纳米压痕法对 PTaG 和 PTiG 的形态、三维结构、成分和力学性能进行了评估。在体外,对两种材料的细胞相容性和矿化能力进行了评估。此外,将 PTaG、PTiG 和 Bio-Oss 填入兔股骨缺损处,8 周后进行显微 CT 和组织学分析。结果表明,PTaG具有分层多孔结构、优异的三维连通性和化学稳定性、合适的力学性能和表面粗糙度、良好的生物相容性和矿化成骨活性,因此骨愈合效果最好。这项工作表明,PTaG 在填充和修复不规则形状的骨缺损方面具有积极的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Tantalum granules with hierarchical pore structure for bone regeneration porous tantalum granules repair bone

Tantalum granules with hierarchical pore structure for bone regeneration porous tantalum granules repair bone

Tantalum (Ta) has good potential for bone tissue engineering due to its excellent corrosion resistance and biocompatibility. However, the customization of Ta-based bone repair materials for irregularly shaped bone defects has been challenging due to their high melting point and hardness. In this work, porous tantalum granules (PTaG) were developed for the first time to repair irregularly shaped bone defects, inspired by the natural phenomenon of sand flow. PTaG were designed as a hierarchical porous structure to regulate the mechanical properties and provide a favorable space for inward growth of cells and tissues. Commercial porous titanium granules (PTiG) and Bio-Oss were used as positive controls to explore the potential of PTaG as bone substitute. The morphology, three-dimensional structure, composition, and mechanical properties of PTaG and PTiG were evaluated by SEM, X-Ray 3D imaging system, 3D laser confocal microscope, EDS, XRD, XPS, and nanoindentation. In vitro, cell compatibility and mineralization ability were evaluated for both materials. Furthermore, PTaG, PTiG, and Bio-Oss were filled in the rabbit femoral defect, and micro-CT and histological analysis were performed after 8 weeks. The results showed that the PTaG had the best bone healing effect due to the hierarchical porous structure, excellent three-dimensional connectivity and chemical stability, suitable mechanical properties and surface roughness, good biocompatibility and mineralization osteogenic activity. This work indicates that PTaG may have a positive potential for filling and repairing irregularly shaped bone defects.

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来源期刊
Journal of Materials Research and Technology-Jmr&t
Journal of Materials Research and Technology-Jmr&t Materials Science-Metals and Alloys
CiteScore
8.80
自引率
9.40%
发文量
1877
审稿时长
35 days
期刊介绍: The Journal of Materials Research and Technology is a publication of ABM - Brazilian Metallurgical, Materials and Mining Association - and publishes four issues per year also with a free version online (www.jmrt.com.br). The journal provides an international medium for the publication of theoretical and experimental studies related to Metallurgy, Materials and Minerals research and technology. Appropriate submissions to the Journal of Materials Research and Technology should include scientific and/or engineering factors which affect processes and products in the Metallurgy, Materials and Mining areas.
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