全脑湍流动力学可预测重度抑郁症患者对药物治疗的反应

IF 9.6 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Anira Escrichs, Yonatan Sanz Perl, Patrick M. Fisher, Noelia Martínez-Molina, Elvira G-Guzman, Vibe G. Frokjaer, Morten L. Kringelbach, Gitte M. Knudsen, Gustavo Deco
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引用次数: 0

摘要

抑郁症是一种多因素临床综合征,药物治疗反应率很低。因此,识别治疗反应的预测因子,为未来开发个性化疗法提供依据至关重要。在这里,我们在健康对照组和未服药抑郁症患者的静息态功能磁共振成像(fMRI)中应用了无模型和基于模型的全脑湍流动力学测量方法。在使用选择性血清素再摄取抑制剂(SSRIs)治疗八周后,根据汉密尔顿抑郁量表 6(HAMD6)将患者分为有反应者和无反应者。通过使用无模型方法,我们发现与健康对照组和应答患者相比,非应答患者在跨时空尺度的信息传递上出现了中断。此外,我们的结果还显示,基线湍流水平与有益的药物治疗结果呈正相关。重要的是,我们的无模型方法能够预测哪些患者会变成无应答者。最后,我们基于模型的方法提供了机理证据,证明无应答患者对刺激的敏感性较低,因此不容易对治疗产生反应。总之,我们证明了不同水平的湍流动力学适用于预测抑郁症患者对 SSRIs 治疗的反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Whole-brain turbulent dynamics predict responsiveness to pharmacological treatment in major depressive disorder

Whole-brain turbulent dynamics predict responsiveness to pharmacological treatment in major depressive disorder

Depression is a multifactorial clinical syndrome with a low pharmacological treatment response rate. Therefore, identifying predictors of treatment response capable of providing the basis for future developments of individualized therapies is crucial. Here, we applied model-free and model-based measures of whole-brain turbulent dynamics in resting-state functional magnetic resonance imaging (fMRI) in healthy controls and unmedicated depressed patients. After eight weeks of treatment with selective serotonin reuptake inhibitors (SSRIs), patients were classified as responders and non-responders according to the Hamilton Depression Rating Scale 6 (HAMD6). Using the model-free approach, we found that compared to healthy controls and responder patients, non-responder patients presented disruption of the information transmission across spacetime scales. Furthermore, our results revealed that baseline turbulence level is positively correlated with beneficial pharmacological treatment outcomes. Importantly, our model-free approach enabled prediction of which patients would turn out to be non-responders. Finally, our model-based approach provides mechanistic evidence that non-responder patients are less sensitive to stimulation and, consequently, less prone to respond to treatment. Overall, we demonstrated that different levels of turbulent dynamics are suitable for predicting response to SSRIs treatment in depression.

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来源期刊
Molecular Psychiatry
Molecular Psychiatry 医学-精神病学
CiteScore
20.50
自引率
4.50%
发文量
459
审稿时长
4-8 weeks
期刊介绍: Molecular Psychiatry focuses on publishing research that aims to uncover the biological mechanisms behind psychiatric disorders and their treatment. The journal emphasizes studies that bridge pre-clinical and clinical research, covering cellular, molecular, integrative, clinical, imaging, and psychopharmacology levels.
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