癌症相关成纤维细胞的分类--好的、坏的和目标

IF 48.8 1区 医学 Q1 CELL BIOLOGY
Lena Cords, Natalie de Souza, Bernd Bodenmiller
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引用次数: 0

摘要

癌症相关成纤维细胞(CAFs)是肿瘤微环境(TME)中异质性的、无处不在的基质细胞。人们通常利用单细胞技术(如单细胞 RNA 测序)描述了许多 CAF 类型。目前还没有CAF的通用分类系统,这阻碍了对它们的研究和靶向治疗。我们根据多种癌症类型中 CAF 的单细胞表型和空间位置提出了一个简单的 CAF 分类系统,评估了我们的方案与现有知识的契合程度,并邀请 CAF 研究界进一步完善该系统。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Classifying cancer-associated fibroblasts—The good, the bad, and the target

Cancer-associated fibroblasts (CAFs) are heterogeneous and ubiquitous stromal cells within the tumor microenvironment (TME). Numerous CAF types have been described, typically using single-cell technologies such as single-cell RNA sequencing. There is no general classification system for CAFs, hampering their study and therapeutic targeting. We propose a simple CAF classification system based on single-cell phenotypes and spatial locations of CAFs in multiple cancer types, assess how our scheme fits within current knowledge, and invite the CAF research community to further refine it.

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来源期刊
Cancer Cell
Cancer Cell 医学-肿瘤学
CiteScore
55.20
自引率
1.20%
发文量
179
审稿时长
4-8 weeks
期刊介绍: Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.
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