罕见的混合性会厌瘤和颗粒细胞瘤:一个小儿病例

IF 1.3 4区 医学 Q3 PATHOLOGY
Kennedy H Sun, Sonia P Goyal, Evelyn M Kim, Esperanza Mantilla-Rivas, Gary F Rogers, Sam P Gulino
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引用次数: 0

摘要

我们报告了一例 13 岁患者的病例,患者下唇长有一个明显的肿瘤,既有颗粒细胞,也有会厌细胞。患者的唇部肿块由来已久,临床感觉很可能是粘液瘤。手术切除后,组织病理学检查发现肿瘤由颗粒细胞组成,S100 蛋白染色阳性,EMA 和 GLUT-1 呈纺锤形细胞阳性,证实为神经外胚层和神经周围混合来源。这是第一例记录18岁以下患者患神经周围细胞-颗粒细胞混合瘤的病例,也是第一例在头颈部报告的病例。该病例拓展了我们对混合型PNST的认识,强调了考虑不同临床表现的重要性,尤其是在非典型部位的罕见儿科病例中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Rare Hybrid Perineurioma and Granular Cell Tumor: A Pediatric Case.

We present a case of a 13-year-old patient with a distinct tumor with both granular cell and perineurial elements, located on the lower lip. The patient presented with a long-standing lip mass that was clinically felt to most likely represent a mucocele. Following surgical excision, histopathological examination revealed a well-circumscribed tumor composed of granular cells with positive S100 protein staining and spindled cells positive for EMA and GLUT-1, confirming mixed neuroectodermal and perineurial origin. This is the first case documenting a perineurial-granular cell hybrid tumor in a patient under 18 years old, and the first to be reported in the head and neck. This case expands our understanding of hybrid PNSTs, emphasizing the importance of considering diverse clinical presentations, especially in the context of rare pediatric occurrences in atypical locations.

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来源期刊
CiteScore
3.70
自引率
5.30%
发文量
59
审稿时长
6-12 weeks
期刊介绍: The Journal covers the spectrum of disorders of early development (including embryology, placentology, and teratology), gestational and perinatal diseases, and all diseases of childhood. Studies may be in any field of experimental, anatomic, or clinical pathology, including molecular pathology. Case reports are published only if they provide new insights into disease mechanisms or new information.
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