Gurjot Kaur Bhatia BDS, MS, Steven M. Levy DDS, MPH, John J. Warren DDS, MS, Oscar A. Rysavy BS, Punam K. Saha BE, ME, PhD, Xiaoliu Zhang PhD, Erliang Zeng BS, MS, PhD
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Because of the multiple statistical analyses being conducted, <i>p</i>-values < 0.01 were considered statistically significant.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>In fully adjusted analyses, no statistically significant (<i>p</i> < 0.01) or suggestive (0.01 < <i>p</i> < 0.05) associations were found between period-specific or cumulative fluoride intake and bone measures for either sex, although there were suggestive positive relationships in unadjusted analyses.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Longitudinal fluoride intakes had little association with bone measures at age 23. As there were no adverse effects from fluoride intake on bone health in young adults, results support the continued use of fluorides, particularly community water fluoridation is the most cost-effective method of dental caries prevention.</p>\n </section>\n </div>","PeriodicalId":16913,"journal":{"name":"Journal of public health dentistry","volume":"84 4","pages":"428-438"},"PeriodicalIF":1.8000,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11619560/pdf/","citationCount":"0","resultStr":"{\"title\":\"Associations between longitudinal fluoride intakes from birth to age 23 and multi-row detector computed tomography bone densitometry outcomes at age 23\",\"authors\":\"Gurjot Kaur Bhatia BDS, MS, Steven M. Levy DDS, MPH, John J. Warren DDS, MS, Oscar A. Rysavy BS, Punam K. 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引用次数: 0
摘要
目标：评估青壮年纵向氟摄入量与骨密度测量结果之间的关系：评估青壮年纵向氟摄入量与骨密度测量结果之间的关系：对爱荷华州氟化物研究和爱荷华州骨骼发育研究的数据进行了分析。通过每1.5-6个月发送一次的详细问卷对每日氟摄入量进行了评估，并对330名23岁的参与者进行了胫骨远端多排探测器计算机断层扫描（MDCT）。通过线性回归分析了性别特异性与 MDCT 结果之间的双变量和多变量关系。由于进行了多项统计分析，因此得出了 p 值 结果：在经过充分调整的分析中，没有发现具有统计学意义的（p 结论）：纵向氟摄入量与 23 岁时的骨骼测量结果几乎没有关联。由于氟摄入量对青壮年的骨骼健康没有不良影响，研究结果支持继续使用氟化物，尤其是社区水氟化是最具成本效益的龋齿预防方法。
Associations between longitudinal fluoride intakes from birth to age 23 and multi-row detector computed tomography bone densitometry outcomes at age 23
Objectives
To assess the relationships between longitudinal fluoride intakes and bone densitometry outcomes in young adults.
Methods
Data were analyzed from the Iowa Fluoride Study and Iowa Bone Development Study, which followed 1,882 infants from birth in 1992. Daily fluoride intakes were assessed using detailed questionnaires sent every 1.5–6 months, and multi-row detector computed tomography (MDCT) scans of distal tibia were obtained from 330 participants aged 23 years. Sex-specific bivariate and multivariable associations with MDCT outcomes were examined using linear regression. Because of the multiple statistical analyses being conducted, p-values < 0.01 were considered statistically significant.
Results
In fully adjusted analyses, no statistically significant (p < 0.01) or suggestive (0.01 < p < 0.05) associations were found between period-specific or cumulative fluoride intake and bone measures for either sex, although there were suggestive positive relationships in unadjusted analyses.
Conclusions
Longitudinal fluoride intakes had little association with bone measures at age 23. As there were no adverse effects from fluoride intake on bone health in young adults, results support the continued use of fluorides, particularly community water fluoridation is the most cost-effective method of dental caries prevention.
期刊介绍：
The Journal of Public Health Dentistry is devoted to the advancement of public health dentistry through the exploration of related research, practice, and policy developments. Three main types of articles are published: original research articles that provide a significant contribution to knowledge in the breadth of dental public health, including oral epidemiology, dental health services, the behavioral sciences, and the public health practice areas of assessment, policy development, and assurance; methods articles that report the development and testing of new approaches to research design, data collection and analysis, or the delivery of public health services; and review articles that synthesize previous research in the discipline and provide guidance to others conducting research as well as to policy makers, managers, and other dental public health practitioners.
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