PARP抑制后的铂化疗在HRR缺陷的转移性阉割耐药前列腺癌中的应用

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-08-10 DOI:10.1016/j.clgc.2024.102187

Jennifer Obasi , Komal Sharma , Navonil De Sarkar , Emmanuel S. Antonarakis , Deepak Kilari

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引用次数: 0

摘要

-在这部分患者中，如果 PARP 抑制剂失效后未检测到逆转突变，可考虑使用卡铂进行挽救。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Platinum Chemotherapy After PARP Inhibition in HRR-Deficient Metastatic Castration-Resistant Prostate Cancer

•
PARP inhibitors can be efficacious in a selected cohort of prostate cancer patients with HRD.
•
A significant fraction of PARP inhibitor resistance occurs due to adoption of PARylation bypass mechanisms, while still maintaining HRRd status in the cancer cell.
•
In this subset of patients, Carboplatin can be considered for salvage if reversion mutations are not detected following PARP inhibitor failure.

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464