轴性脊柱关节炎中的肠道微生物群:遗传学、药物和未来疗法。

IF 1.4 4区 医学 Q3 RHEUMATOLOGY
ARP Rheumatology Pub Date : 2024-07-01 DOI:10.63032/WUII1201
Nehal Yemula, Riyad Sheikh
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引用次数: 0

摘要

轴性脊柱关节炎又称强直性脊柱炎,是一种慢性炎症,主要影响轴性脊柱,但也可能伴有外周关节炎。它属于脊柱关节病的范畴。除轴性脊柱关节炎外,这一组疾病还包括银屑病关节炎、肠病性关节炎、反应性关节炎和未分化脊柱关节病,其中轴性脊柱关节炎是最常见的疾病之一。轴性脊柱关节炎的总体发病机制是复杂和多因素的。轴性脊柱关节炎与 HLA-B27 基因之间存在明显的、公认的关联,但在疾病过程中也发现了非 HLA 基因,以及某些在炎症过程中发挥作用的炎性细胞因子,如肿瘤坏死因子(TNF)。最近,有研究和新证据表明,肠道微生物群的变化与轴性脊柱关节炎的发病过程有关。对肠道微生物群的作用和肠道菌群失调的研究是一个庞大且不断发展的领域。它与包括轴性脊柱关节炎在内的多种疾病有关。这篇微型综述重点介绍了肠道微生物群与轴性脊柱关节炎的发病机制、治疗药物和未来治疗方法之间的共生关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gut microbiota in axial spondyloarthritis : genetics, medications and future treatments.

Axial spondyloarthritis, also referred to as ankylosing spondylitis, is a chronic inflammatory condition that predominantly affects the axial spine but may also present with peripheral arthritis. It falls within the umbrella of disorders known as spondyloarthropathies. In addition to axial spondyloarthritis, this group includes psoriatic arthritis, enteropathic arthritis, reactive arthritis, and undifferentiated spondyloarthropathy, with axial spondyloarthritis being one of the most common. The overall mechanisms underlying the development of axial spondyloarthritis are complex and multifactorial. There is a significant and well-recognized association between axial spondyloarthritis and the HLA-B27 gene, but there have also been non-HLA genes identified in the disease process, as well as certain inflammatory cytokines that play a role in the inflammatory process, such as tumor necrosis factor (TNF). More recently, there has been research and new evidence linking changes in the gut microbiota to the disease process of axial spondyloarthritis. Research into the role of the gut microbiota and gut dysbiosis is a large, ever-growing field. It has been associated with a multitude of conditions, including axial spondyloarthritis. This mini-review highlights the symbiotic relationship of the gut microbiota with the pathogenesis, therapeutic agents and future treatments of axial spondyloarthritis.

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