阿尔茨海默病血浆生物标志物的导航：聚焦过去、现在和未来的临床应用。

IF 3.9 3区医学 Q1 CLINICAL NEUROLOGY

Neurology and Therapy Pub Date : 2024-12-01 Epub Date: 2024-09-07 DOI:10.1007/s40120-024-00658-x

Sarrah E Ankeny, Julia R Bacci, Boris Decourt, Marwan N Sabbagh, Michelle M Mielke

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引用次数: 0

摘要

随着阿尔茨海默病（AD）发病率的增加及其对医疗保健系统的影响，开发准确诊断和监测疾病进展的工具成为当务之急。最近的技术进步使得基于血液的生物标记物（BBMs）的开发成为可能，以帮助诊断阿尔茨海默病，但在这些 BBMs 的临床应用方面仍存在许多问题。本综述概述了 AD BBM 开发的历史进程。它强调了一些关键突破，这些突破将注意力缺失症生物标记物的视角从理论上理想但无法实现的标记物转变为临床上有效且可靠的生物标记物，并有可能在医疗保健环境中实施。单分子检测和质谱方法等技术进步大大提高了检测灵敏度和准确性。高通量、全自动平台具有临床应用潜力。尽管取得了这些进步，但在广泛的临床实践中应用 AD BBMs 之前，仍有大量工作要做。必须确定切点，必须更好地了解慢性疾病和药物对 BBM 水平的影响，还必须为医疗服务提供者制定有关解释和交流从 AD BBMs 中获得的信息的指南。此外，针对突触功能障碍、炎症和脑血管疾病的 BBM 的开发可能会为治疗 AD 和相关痴呆症提供更好的精准医疗方法。未来的研究以及科学家和医生之间的合作对于应对这些挑战和进一步推进AD BBMs至关重要，其目标是将BBMs纳入临床实践。

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Navigating the Landscape of Plasma Biomarkers in Alzheimer's Disease: Focus on Past, Present, and Future Clinical Applications.

As the prevalence of Alzheimer's disease (AD) and its impact on healthcare systems increase, developing tools for accurate diagnosis and monitoring of disease progression is a priority. Recent technological advancements have allowed for the development of blood-based biomarkers (BBMs) to aid in the diagnosis of AD, but many questions remain regarding the clinical implementation of these BBMs. This review outlines the historical timeline of AD BBM development. It highlights key breakthroughs that have transformed the perspective of AD BBMs from theoretically ideal but unattainable markers, to clinically valid and reliable BBMs with potential for implementation in healthcare settings. Technological advancements like single-molecule detection and mass spectrometry methods have significantly improved assay sensitivity and accuracy. High-throughput, fully automated platforms have potential for clinical use. Despite these advancements, however, significant work is needed before AD BBMs can be implemented in widespread clinical practice. Cutpoints must be established, the influence of chronic conditions and medications on BBM levels must be better understood, and guidelines must be created for healthcare providers related to interpreting and communicating information obtained from AD BBMs. Additionally, the development of BBMs for synaptic dysfunction, inflammation, and cerebrovascular disease may provide better precision medicine approaches to treating AD and related dementia. Future research and collaboration between scientists and physicians are essential to addressing these challenges and further advancing AD BBMs, with the goal of integration in clinical practice.

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来源期刊

Neurology and Therapy CLINICAL NEUROLOGY-

CiteScore

5.40

自引率

8.10%

发文量

103

审稿时长

6 weeks

期刊介绍： Aims and Scope Neurology and Therapy aims to provide reliable and inclusive, rapid publication for all therapy related research for neurological indications, supporting the timely dissemination of research with a global reach, to help advance scientific discovery and support clinical practice. Neurology and Therapy is an international, open access, peer reviewed, rapid publication journal dedicated to the publication of high-quality clinical (all phases), observational, real-world and health outcomes research around the discovery, development, and use of neurological and psychiatric therapies, (also covering surgery and devices). Studies relating to diagnosis, pharmacoeconomics, public health, quality of life, and patient care, management, and education are also welcomed. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, case reports, trial designs, communications and letters. 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