催产素能系统与移情神经活动中的种族同群偏差》(The Oxytocinergic System and Racial Ingroup Bias in Empathic Neural Activity.

IF 4.6 2区 医学 Q1 NEUROSCIENCES
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引用次数: 0

摘要

研究表明,与外群体相比,人脑对同一种族内群体的个体表现出更强烈的神经移情反应。然而,催产素能系统对涉及共情中种族内群偏向(RIBE)的大脑区域之间动态连接的影响及其对现实生活中社会互动意向的影响仍不清楚。为了填补这一空白,我们采用功能性磁共振成像(fMRI)研究了RIBE调节的神经活动以及催产素能系统在神经和行为层面的影响。催产素受体基因(OXTR)rs53576多态性的A/A和G/G基因型同卵双生的参与者在接受催产素(OT)或安慰剂治疗后,在同种族或其他种族场景中对疼痛与非疼痛刺激做出判断时接受了扫描。结果显示,与其他种族模型相比,G/G 组的前扣带回皮层(ACC)和前岛叶(AI)对同种族模型的反应更活跃,而 A/A 组则不然。RIBE还调节了双侧AI和ACC之间的连接,OT对这种调节作用的影响受基因型rs53576和人际信任的调节。此外,在低人际信任组中,AI-ACC 连接的更广泛变化与更高水平的报复意向相关。总之,我们的研究结果表明,在人际交往中,催产素能系统在RIBE调节的神经活动和报复意向中起着关键作用,并受人际信任的调节作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The oxytocinergic system and racial ingroup bias in empathic neural activity

Studies have indicated that the human brain exhibits a more robust neural empathic response towards individuals of the same racial ingroup than those of the outgroup. However, the impact of the oxytocinergic system on the dynamic connectivity between brain regions involved in racial ingroup bias in empathy (RIBE) and its implications for real-life social interaction intention remains unclear. To address this gap, we employed functional magnetic resonance imaging (fMRI) to investigate RIBE-modulated neural activities and the influence of the oxytocinergic system at both neural and behavioral levels. Participants homozygous for the A/A and G/G genotypes of the oxytocin receptor gene (OXTR) rs53576 polymorphism underwent scanning while making judgments about painful versus non-painful stimuli in same-race versus other-race scenarios following either oxytocin (OT) or placebo treatment. The results revealed greater activity in the anterior cingulate cortex (ACC) and anterior insula (AI) in response to same-race compared to other-race models in the G/G group but not in the A/A group. RIBE also modulated the connections between bilateral AI and the ACC, and the effect of OT on this modulatory effect was moderated by genotype rs53576 and interpersonal trust. Moreover, more extensive changes in AI-ACC connections were associated with higher levels of revenge intention in the low interpersonal trust group. Overall, our findings suggest a pivotal role of the oxytocinergic system in the RIBE-modulated neural activities and revenge intention in human interactions with the modulatory effect of interpersonal trust.

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来源期刊
Neuropharmacology
Neuropharmacology 医学-神经科学
CiteScore
10.00
自引率
4.30%
发文量
288
审稿时长
45 days
期刊介绍: Neuropharmacology publishes high quality, original research and review articles within the discipline of neuroscience, especially articles with a neuropharmacological component. However, papers within any area of neuroscience will be considered. The journal does not usually accept clinical research, although preclinical neuropharmacological studies in humans may be considered. The journal only considers submissions in which the chemical structures and compositions of experimental agents are readily available in the literature or disclosed by the authors in the submitted manuscript. Only in exceptional circumstances will natural products be considered, and then only if the preparation is well defined by scientific means. Neuropharmacology publishes articles of any length (original research and reviews).
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