美国成人肥胖症患者的生活必需品 8 和死亡率：一项队列研究。

IF 3.7 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Endocrine Practice Pub Date : 2024-11-01 DOI:10.1016/j.eprac.2024.08.015

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引用次数: 0

摘要

目的：本研究利用美国国家健康与人口调查（NHANES）数据，评估了生活必需品 8（LE8）评分系统与肥胖者全因和特定原因死亡率之间的关系：本研究利用 NHANES 数据评估了生活必需品 8（LE8）评分系统与肥胖者全因和特定原因死亡率之间的关系：分析了 2005 年至 2018 年间收集的 9143 名肥胖参与者（体重指数≥30 kg/m2）的数据。根据LE8得分对参与者进行分类：低心血管健康（Low CVH，n=2264）、中度心血管健康（Moderate CVH，n=6541）和高心血管健康（High CVH，n=338）。采用卡普兰-米尔生存分析和考克斯比例危险模型评估了LE8评分与死亡率之间的关系：中位随访时间为 7.3 年，共有 867 例全因死亡（9.5%），其中包括 246 例心血管疾病 (CVD) 死亡（2.7%）和 621 例非 CVD 死亡（6.8%）。在多变量 Cox 回归分析中，与低 CVH 组相比，中度 CVH 组的全因死亡率调整后危险比 (HR) 为 0.63（95% CI：0.55-0.72），而高度 CVH 组的 HR 为 0.25（95% CI：0.10-0.60）。在心血管疾病死亡率方面，中度 CVH 组的 HR 为 0.61（95% CI：0.47-0.78），高度 CVH 组的 HR 为 0.19（95% CI：0.03-1.38）。在非心血管疾病死亡率方面，中度 CVH 的 HR 为 0.64（95% CI：0.54-0.75），高度 CVH 为 0.27（95% CI：0.10-0.72）。LE8得分每增加10分，全因死亡率就会降低20%（结论：LE8得分越高，全因死亡率就会显著降低：LE8 评分越高，肥胖者的全因死亡率、心血管疾病死亡率和非心血管疾病死亡率就越低。这些研究结果表明，LE8 评分系统可有效预测健康状况和死亡风险。

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Life’s Essential 8 and Mortality in US Adults With Obesity: A Cohort Study

Objective

This study evaluates the relationship between the Life’s Essential 8 (LE8) scoring system and all-cause and cause-specific mortality among obese individuals using National Health and Nutrition Examination Survey data.

Methods

Data from 9143 obese participants (BMI ≥30 kg/m²) collected between 2005 and 2018 were analyzed. Participants were categorized based on their LE8 scores: low cardiovascular health (Low CVH, n = 2264), moderate cardiovascular health (Moderate CVH, n = 6541), and high cardiovascular health (High CVH, n = 338). Associations between LE8 scores and mortality were assessed using Kaplan-Meier survival analysis and Cox proportional hazards models.

Results

Over a median follow-up of 7.3 years, there were 867 all-cause deaths (9.5%), including 246 cardiovascular disease (CVD) deaths (2.7%) and 621 non-CVD deaths (6.8%). In multivariable Cox regression analysis, compared to the Low CVH group, the Moderate CVH group had an adjusted hazard ratio (HR) for all-cause mortality of 0.63 (95% CI: 0.55-0.72), and the High CVH group had an HR of 0.25 (95% CI: 0.10-0.60). For CVD mortality, the HRs were 0.61 (95% CI: 0.47-0.78) for Moderate CVH and 0.19 (95% CI: 0.03-1.38) for High CVH. For non-CVD mortality, the HRs were 0.64 (95% CI: 0.54-0.75) for Moderate CVH and 0.27 (95% CI: 0.10-0.72) for High CVH. Each 10-point increase in LE8 score was associated with a 20% reduction in all-cause mortality (P < .001), 21% reduction in CVD mortality (P < .001), and 20% reduction in non-CVD mortality (P < .001).

Conclusion

Higher LE8 scores are significantly associated with lower rates of all-cause, CVD, and non-CVD mortality among obese individuals. These findings support the LE8 scoring system as an effective predictor of health status and mortality risk.

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来源期刊

Endocrine Practice ENDOCRINOLOGY & METABOLISM-

CiteScore

7.60

自引率

2.40%

发文量

546

审稿时长

41 days

期刊介绍： Endocrine Practice (ISSN: 1530-891X), a peer-reviewed journal published twelve times a year, is the official journal of the American Association of Clinical Endocrinologists (AACE). The primary mission of Endocrine Practice is to enhance the health care of patients with endocrine diseases through continuing education of practicing endocrinologists.