由癌症相关成纤维细胞衍生的细胞外囊泡介导的癌症耐药性：从生物学机制到临床意义和影响

IF 27.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cancer Pub Date : 2024-09-07 DOI:10.1186/s12943-024-02106-8

Zhengjun Lin, Guoqing Li, Ke Jiang, Zhihong Li, Tang Liu

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引用次数: 0

摘要

癌症相关成纤维细胞（CAFs）是肿瘤微环境中的一个多样化基质细胞群，它们在癌症进展和患者预后中发挥着重要作用。多种证据表明，CAFs 关键性地参与了肿瘤微环境结构和功能的形成，在调节肿瘤行为（如转移、侵袭和上皮-间质转化（EMT））方面具有多种功能。CAF可通过产生胞外囊泡（EV）、多种分泌因子和代谢产物与癌细胞广泛互动。值得注意的是，CAF衍生的EVs已被确定为癌症耐药性的关键介质，并在癌症治疗中成为新的治疗靶点和生物标志物。本综述旨在总结 CAF 衍生的 EVs 在介导癌症对化疗、靶向治疗药物、放疗和免疫疗法的耐药性方面的生物学作用和详细的分子机制。我们还讨论了CAF衍生EVs作为癌症临床治疗的新靶点和临床生物标志物的治疗潜力，从而为提高癌症疗效和改善患者预后提供一种新的治疗策略。

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Cancer therapy resistance mediated by cancer-associated fibroblast-derived extracellular vesicles: biological mechanisms to clinical significance and implications

Cancer-associated fibroblasts (CAFs) are a diverse stromal cell population within the tumour microenvironment, where they play fundamental roles in cancer progression and patient prognosis. Multiple lines of evidence have identified that CAFs are critically involved in shaping the structure and function of the tumour microenvironment with numerous functions in regulating tumour behaviours, such as metastasis, invasion, and epithelial-mesenchymal transition (EMT). CAFs can interact extensively with cancer cells by producing extracellular vesicles (EVs), multiple secreted factors, and metabolites. Notably, CAF-derived EVs have been identified as critical mediators of cancer therapy resistance, and constitute novel therapy targets and biomarkers in cancer management. This review aimed to summarize the biological roles and detailed molecular mechanisms of CAF-derived EVs in mediating cancer resistance to chemotherapy, targeted therapy agents, radiotherapy, and immunotherapy. We also discussed the therapeutic potential of CAF-derived EVs as novel targets and clinical biomarkers in cancer clinical management, thereby providing a novel therapeutic strategy for enhancing cancer therapy efficacy and improving patient prognosis.

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来源期刊

Molecular Cancer 医学-生化与分子生物学

CiteScore

54.90

自引率

2.70%

发文量

224

审稿时长

2 months

期刊介绍： Molecular Cancer is a platform that encourages the exchange of ideas and discoveries in the field of cancer research, particularly focusing on the molecular aspects. Our goal is to facilitate discussions and provide insights into various areas of cancer and related biomedical science. We welcome articles from basic, translational, and clinical research that contribute to the advancement of understanding, prevention, diagnosis, and treatment of cancer. The scope of topics covered in Molecular Cancer is diverse and inclusive. These include, but are not limited to, cell and tumor biology, angiogenesis, utilizing animal models, understanding metastasis, exploring cancer antigens and the immune response, investigating cellular signaling and molecular biology, examining epidemiology, genetic and molecular profiling of cancer, identifying molecular targets, studying cancer stem cells, exploring DNA damage and repair mechanisms, analyzing cell cycle regulation, investigating apoptosis, exploring molecular virology, and evaluating vaccine and antibody-based cancer therapies. Molecular Cancer serves as an important platform for sharing exciting discoveries in cancer-related research. It offers an unparalleled opportunity to communicate information to both specialists and the general public. The online presence of Molecular Cancer enables immediate publication of accepted articles and facilitates the presentation of large datasets and supplementary information. This ensures that new research is efficiently and rapidly disseminated to the scientific community.