头颈癌患者恶性伤口的预后影响：前瞻性队列研究的二次分析。

IF 2.5 4区医学 Q3 ONCOLOGY

Cancer Control Pub Date : 2024-01-01 DOI:10.1177/10732748241274216

Shigemasa Takamizawa, Hiroto Ishiki, Yuma Takeda, Sayaka Arakawa, Naruaki Kawasaki, Isseki Maeda, Naosuke Yokomichi, Takashi Yamaguchi, Hiroyuki Otani, Tatsuya Morita, Eriko Satomi, Masanori Mori

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引用次数: 0

摘要

简介恶性伤口是由远处原发癌症转移或原发癌症直接侵犯皮肤结构引起的病变，最常见于乳腺癌或头颈部癌症患者。恶性伤口不仅会引起身体症状，还会影响患者的生存。了解晚期癌症患者的预后对患者和医护人员都很有必要。头颈部癌症患者恶性伤口对预后的影响尚未得到充分研究：本研究是对一项前瞻性队列研究结果的二次分析，该研究调查了日本 23 家姑息治疗机构中晚期癌症患者的死亡过程。这项研究的主要结果是恶性伤口对头颈部癌症患者预后的影响。采用对数秩检验比较了有恶性伤口和无恶性伤口的头颈部癌症患者的生存率差异：在姑息治疗病房收治的 1896 名患者中，68 人患有头颈部癌症，其中 29 人有恶性伤口。有恶性伤口的患者的总生存期明显短于无恶性伤口的患者（中位数：19.0 天 vs 32.0 天，P = 0.046）：结论：有恶性伤口的头颈部癌症患者的总生存期比没有恶性伤口的患者更短。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Prognostic Impact of Malignant Wounds in Patients With Head and Neck Cancer: Secondary Analysis of a Prospective Cohort Study.

Introduction: Malignant wounds are lesions caused by metastasis from distant primary cancers or by direct invasion of the cutaneous structures of a primary cancer, and are most common in patients with breast or head and neck cancers. Malignant wounds not only cause physical symptoms, but also affect survival. Recognizing prognosis in terminal-stage cancer patients is necessary for both patients and health care providers. The prognostic impact of malignant wounds in patients with head and neck cancer has been poorly investigated.

Methods: This is a secondary analysis of the results of a prospective cohort study that investigated the dying process in patients with advanced cancer in 23 palliative care units in Japan. The primary outcome of this study was the prognostic impact of malignant wounds in patients with head and neck cancer. The difference in survival between patients with head and neck cancer who had malignant wounds and those who did not was compared using the log-rank test.

Results: Of 1896 patients admitted to palliative care units, 68 had head and neck cancer, and 29 of these had malignant wounds. Overall survival was significantly shorter in patients with malignant wounds than that in those without (median: 19.0 days vs 32.0 days, P = 0.046).

Conclusion: Patients with head and neck cancer who had malignant wounds had worse overall survival than those who did not.

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来源期刊

Cancer Control ONCOLOGY-

CiteScore

3.80

自引率

0.00%

发文量

148

审稿时长

>12 weeks

期刊介绍： Cancer Control is a JCR-ranked, peer-reviewed open access journal whose mission is to advance the prevention, detection, diagnosis, treatment, and palliative care of cancer by enabling researchers, doctors, policymakers, and other healthcare professionals to freely share research along the cancer control continuum. Our vision is a world where gold-standard cancer care is the norm, not the exception.