亟待了解:干洗工人的间质性肺病。

Ross Summer, Phoebe Chun
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引用次数: 0

摘要

间质性肺病(ILD)是一组以肺间质炎症和纤维化为特征的异质性疾病。间质性肺病的危险因素包括各种环境暴露,识别特定的环境暴露为预防疾病提供了干预点。在此,我们介绍了几例曾在干洗行业工作并患有 ILD 或胸部 CT 成像出现与早期 ILD 一致的异常的患者。虽然本报告并不试图确定因果关系,但我们假设,接触工业溶剂四氯乙烯可能是一个诱因,因为它与上皮损伤、炎症、氧化还原失衡和细胞凋亡有关。我们希望本报告不仅能让读者了解干洗与 ILD 之间可能存在的联系,还能为更多有关四氯乙烯对肺部影响的研究奠定基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pressed for understanding: Interstitial lung disease in dry-cleaning workers.

Interstitial lung disease (ILD) represents a heterogeneous group of disorders characterized by inflammation and fibrosis of the pulmonary interstitium. Risk factors for ILD include various environmental exposures and identifying specific exposures offers a point of intervention for preventing disease. Here, we present several cases of patients who worked in the dry-cleaning business and have ILD or abnormalities consistent with early ILD on chest CT imaging. While this report does not attempt to establish causality, we hypothesize that exposure to the industrial solvent tetrachloroethylene may serve as a contributing factor given its links to epithelial injury, inflammation, redox imbalance and apoptosis. We hope that this report serves to not only inform readers of this possible connection between dry cleaning and ILD but also lay the foundation for additional studies examining the effects of tetrachloroethylene on the lung.

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