细胞间线粒体转移：新的疾病治疗机制。

IF 3.6 3区生物学 Q3 CELL BIOLOGY

Traffic Pub Date : 2024-09-01 DOI:10.1111/tra.12951

Huimei Liu, Hui Mao, Xueqian Ouyang, Ruirui Lu, Lanfang Li

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引用次数: 0

摘要

线粒体是负责能量生产和细胞代谢的动态细胞器，具有从营养物质中提取能量和合成重要代谢产物的代谢功能。然而，最近的研究发现，通过隧道纳米管、肿瘤微管、缝隙连接细胞间通信、细胞外囊泡、内吞和细胞融合进行的细胞间线粒体转移可能会调节受体细胞内的线粒体功能，从而为非酒精性脂肪性肝炎、胶质母细胞瘤、缺血性中风、膀胱癌和神经退行性疾病等疾病的治疗做出潜在贡献。本综述介绍了细胞间线粒体转移的主要方法，并探讨了线粒体转移在各种疾病中的作用。此外，我们还全面概述了细胞间线粒体转运的抑制剂和激活剂，以独特的视角说明细胞间线粒体转运与疾病之间的关系。

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Intercellular Mitochondrial Transfer: The Novel Therapeutic Mechanism for Diseases.

Mitochondria, the dynamic organelles responsible for energy production and cellular metabolism, have the metabolic function of extracting energy from nutrients and synthesizing crucial metabolites. Nevertheless, recent research unveils that intercellular mitochondrial transfer by tunneling nanotubes, tumor microtubes, gap junction intercellular communication, extracellular vesicles, endocytosis and cell fusion may regulate mitochondrial function within recipient cells, potentially contributing to disease treatment, such as nonalcoholic steatohepatitis, glioblastoma, ischemic stroke, bladder cancer and neurodegenerative diseases. This review introduces the principal approaches to intercellular mitochondrial transfer and examines its role in various diseases. Furthermore, we provide a comprehensive overview of the inhibitors and activators of intercellular mitochondrial transfer, offering a unique perspective to illustrate the relationship between intercellular mitochondrial transfer and diseases.

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来源期刊

Traffic 生物-细胞生物学

CiteScore

8.10

自引率

2.20%

发文量

审稿时长

2 months

期刊介绍： Traffic encourages and facilitates the publication of papers in any field relating to intracellular transport in health and disease. Traffic papers span disciplines such as developmental biology, neuroscience, innate and adaptive immunity, epithelial cell biology, intracellular pathogens and host-pathogen interactions, among others using any eukaryotic model system. Areas of particular interest include protein, nucleic acid and lipid traffic, molecular motors, intracellular pathogens, intracellular proteolysis, nuclear import and export, cytokinesis and the cell cycle, the interface between signaling and trafficking or localization, protein translocation, the cell biology of adaptive an innate immunity, organelle biogenesis, metabolism, cell polarity and organization, and organelle movement. All aspects of the structural, molecular biology, biochemistry, genetics, morphology, intracellular signaling and relationship to hereditary or infectious diseases will be covered. Manuscripts must provide a clear conceptual or mechanistic advance. The editors will reject papers that require major changes, including addition of significant experimental data or other significant revision. Traffic will consider manuscripts of any length, but encourages authors to limit their papers to 16 typeset pages or less.