利用 PROOF 研究的真实世界数据预测抗血管内皮生长因子治疗新生血管性老年黄斑变性后的疾病活动。
IF 2.6
3区 医学
Q2 OPHTHALMOLOGY
Ophthalmology and Therapy
Pub Date : 2024-11-01
Epub Date: 2024-09-05
DOI:10.1007/s40123-024-01021-x
引用次数: 0
摘要
简介本研究旨在调查在真实世界条件下，抗血管内皮生长因子（anti-VEGF）治疗新生血管性年龄相关性黄斑变性（nAMD）患者持续性疾病活动的预测因素及其长期影响：对PROOF研究进行了回顾性数据分析，该研究是在韩国各地对nAMD患者进行的多中心真实世界回顾性病历审查，包括2017年1月至2019年3月期间首次接受抗血管内皮生长因子（雷尼珠单抗、贝伐珠单抗或阿弗利贝赛普）治疗的未接受治疗的nAMD患者。所有600名患者（队列1）的随访时间至少为12个月，其中453名患者（队列2）的随访时间为自基线起24个月：抗 VEGF 治疗后第 12 个月，58.10%（95% 置信区间 [CI]：54.09, 62.12）的患者仍有持续视网膜积液；第 24 个月，66.02% 的患者仍有持续视网膜积液。在第 12 个月和第 24 个月，预测持续性疾病活动的因素是纤维血管性色素上皮脱离（PED）（P = 0.0494）和负荷阶段后第 3 个月的视网膜积液（P = 0.0082）。贝伐珠单抗组、阿弗利百普组和雷尼珠单抗组在12个月时视力的平均变化分别为+ 6.2、+ 10.1和+ 13.3个字母，中央子场厚度的平均变化分别为- 79.1微米、- 96.3微米和- 134.4微米：负荷期后出现视网膜积液和纤维血管性PED是抗VEGF治疗至少1年后疾病活动持续存在的预测因素。本文章由计算机程序翻译，如有差异，请以英文原文为准。
Predictors of Disease Activity After Anti-VEGF Treatment for Neovascular Age-Related Macular Degeneration Using Real-World Data from the PROOF Study.
Introduction: The aim of this study was to investigate the predictive factors for persistent disease activity following anti-vascular endothelial growth factors (anti-VEGF) and their long-term effects in patients to be treated for neovascular age-related macular degeneration (nAMD) under real-world conditions.
Methods: Retrospective data analysis of the PROOF study, a multi-center real-world retrospective chart review conducted across Korea in patients with nAMD included treatment-naive patients with nAMD who received first anti-VEGF (ranibizumab, bevacizumab, or aflibercept) between January 2017 and March 2019 was performed. All 600 patients (cohort 1) had a minimum follow-up of 12 months of which 453 patients (cohort 2) were followed-up for 24 months from baseline.
Results: At month 12 after anti-VEGF therapy, 58.10% (95% confidence interval [CI]: 54.09, 62.12) of patients and at month 24, 66.02% of patients continued to have persistent retinal fluid. At both months 12 and 24, predictive factors for persistent disease activity were fibrovascular pigment epithelial detachments (PED) (P = 0.0494) and retinal fluid at month 3 after loading phase (P = 0.0082). The mean changes in visual acuity were + 6.2, + 10.1, and + 13.3 letters and in the central subfield thickness were - 79.1 µm, - 96.3 µm, and - 134.4 µm at 12 months from baseline, in the bevacizumab, aflibercept, and ranibizumab groups, respectively.
Conclusions: The presence of retinal fluid after loading phase and fibrovascular PED were predictors of persistent disease activity after at least 1 year of anti-VEGF treatment.
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来源期刊
Ophthalmology and Therapy
OPHTHALMOLOGY-
CiteScore
4.20
自引率
3.00%
发文量
157
审稿时长
6 weeks
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Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques.
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