在全国代表性样本中调查脂肪肝与慢性肾脏病之间的关联。

IF 3.2 Q1 UROLOGY & NEPHROLOGY
Kidney360 Pub Date : 2024-09-05 DOI:10.34067/KID.0000000569
Mason Lai, Jennifer C Lai, Andrew S Allegretti, Kavish R Patidar, Giuseppe Cullaro
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引用次数: 0

摘要

背景:脂肪肝(SLD)和慢性肾脏病(CKD)是密切相关的常见疾病。然而,有关这种重叠的流行率以及可能导致其发生的因素的数据却很少:我们利用全国健康与营养调查,研究了 2005-2020 年间用脂肪肝指数定义 SLD 的成年参与者的趋势。我们对 2017-2020 年根据纤维扫描结果定义 SLD 的成年参与者进行了相关分析。我们利用多变量调查加权二项式广义线性模型来确定与慢性肾功能衰竭(定义为 eGFR 30)相关的因素:在纳入趋势分析的 76496 名参与者中,估计的 CKD 患病率为 15.7%(95%CI 15.2 - 16.2%),SLD 患病率为 42.3%(95%CI 41.4 - 43.2%)。与没有 SLD 的人相比,有 SLD 的人估计的 CKD 患病率明显更高(SLD:15.7%,95%CI 14.9 - 16.5% 与无 SLD 11.2%,95%CI 10.7 - 11.7%)。在对 3,667 名接受了纤维扫描并根据脂肪肝指数患有 SLD 的参与者进行的多变量分析中,调整了控制和是否患有 DM、HTN 和 HLD,与肝硬度正常者相比,中度瘢痕(F2)者患 CKD 的几率相似(1.53,95CI 0.91-2.56),重度瘢痕(F3)者患 CKD 的几率更高(2.28,95CI 1.20-4.32),肝硬化者患 CKD 的几率更高(2.21,95CI 1.13-4.32):我们的研究结果表明,在SLD患者中,慢性肾功能衰竭很常见,肝纤维化程度越高,慢性肾功能衰竭的发生率越高,这与代谢综合征的其他并发症无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigating the Association between Steatotic Liver Disease and CKD in a Nationally Representative Sample.

Background: Steatotic liver disease (SLD) and chronic kidney disease (CKD) are common conditions that are strongly associated. Yet, there is a paucity of data regarding the prevalence of this overlap and the factors that may drive its occurrence.

Methods: Using the National Health and Nutrition Examination survey, we examined trends among adult participants from 2005 - 2020 that defined SLD with the Fatty Liver Index. We completed correlative analyses among adult participants from 2017 - 2020 that defined SLD based on FibroScan results. We utilized multivariable survey-weighted binomial generalized linear models to determine the factors that were associated with CKD, defined as eGFR <60 or urine albumin-creatinine-ratio >30.

Results: Among the 76,496 participants included in the trend analyses, the estimated prevalence of CKD was 15.7% (95%CI 15.2 - 16.2%) and SLD was 42.3% (95%CI 41.4 - 43.2%). As compared to those without SLD, those with SLD had a significantly higher estimated prevalence of CKD (SLD: 15.7%, 95%CI 14.9 - 16.5% v. No SLD 11.2%, 95%CI 10.7 - 11.7%). In multivariate analyses of 3,667 participants who underwent FibroScan and had SLD by Fatty Liver Index, adjusting for control and presence of DM, HTN, and HLD, compared to those with normal liver stiffness, those with moderate scarring (F2) had similar odds of CKD (1.53, 95CI 0.91-2.56), those with severe scarring (F3) had higher odds of CKD (2.28, 95CI 1.20-4.32), and those with cirrhosis had higher odds of CKD (2.21, 95CI 1.13-4.32).

Conclusions: Our findings highlight that CKD is common among patients with SLD and that higher degrees of hepatic fibrosis are associated with CKD, independent of other co-morbidities of the metabolic syndrome.

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来源期刊
Kidney360
Kidney360 UROLOGY & NEPHROLOGY-
CiteScore
3.90
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