Luke R. Murphy MD , Adam Singer MD , Brandon Okeke BS , Krishna Paul BS , Matthew Talbott DO , Dietrich Jehle MD
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Patients aged 18 years or older with a PE diagnosis (International Classification of Diseases, 10<sup>th</sup> Revision, Clinical Modification code I26) were included. The following two cohorts were defined: TNK-treated (29 organizations, 266 cases) and alteplase-treated (22,864 cases). Propensity matching controlled for demographic characteristics, anticoagulant use, pre-existing conditions, and vital sign abnormalities associated with PE severity. Patients received TNK or alteplase within 7 days of diagnosis and outcomes were measured at 30 days post thrombolysis.</p></div><div><h3>Results</h3><p>Two hundred eighty-three patients in each cohort were comparable in demographic characteristics and pre-existing conditions. Mortality rates at 30 days post thrombolysis were similar between TNK and alteplase cohorts (19.4% vs 19.8%; risk ratio 0.982; 95% CI 0.704–1.371). Rates of intracerebral hemorrhages and transfusion were too infrequent to analyze.</p></div><div><h3>Conclusions</h3><p>This study found TNK to exhibit a similar mortality rate to alteplase in the treatment of PE with hemodynamic instability. The results necessitate prospective evaluation. Given the cost-effectiveness and ease of administration of TNK, these findings contribute to the ongoing discussion about its adoption as a primary thrombolytic agent for stroke and PE.</p></div>","PeriodicalId":16085,"journal":{"name":"Journal of Emergency Medicine","volume":"67 5","pages":"Pages e432-e441"},"PeriodicalIF":1.2000,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mortality Outcomes with Tenecteplase Versus Alteplase in the Treatment of Massive Pulmonary Embolism\",\"authors\":\"Luke R. 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引用次数: 0
摘要
背景：肺栓塞（PE）每年导致许多人到急诊科就诊。目前，阿替普酶等溶栓药物被推荐用于治疗大面积肺栓塞，但转基因替奈普酶（TNK）具有优势。关于 TNK 和阿替普酶治疗 PE 的比较研究有限：本研究旨在利用从大型多中心登记处获得的实际证据，评估 TNK 与阿替普酶在 PE 患者中的安全性和死亡率。主要结果包括死亡率、颅内出血和输血：这项回顾性队列研究使用了 TriNetX 全球健康研究网络。研究纳入了年龄在 18 岁或 18 岁以上、确诊为 PE（《国际疾病分类》第 10 版，临床修改代码 I26）的患者。定义了以下两个队列：TNK治疗组（29个组织，266个病例）和阿替普酶治疗组（22864个病例）。倾向匹配控制了与 PE 严重程度相关的人口统计学特征、抗凝药物使用、既往病症和生命体征异常。患者在确诊后 7 天内接受 TNK 或阿替普酶治疗，结果在溶栓后 30 天进行测量：结果：每个队列中的 283 名患者在人口统计学特征和原有病症方面具有可比性。TNK 组和阿替普酶组溶栓后 30 天的死亡率相似（19.4% vs 19.8%；风险比 0.982；95% CI 0.704-1.371）。脑出血和输血的发生率较低，无法进行分析：本研究发现，在治疗血流动力学不稳定的 PE 时，TNK 的死亡率与阿替普酶相似。有必要对研究结果进行前瞻性评估。考虑到 TNK 的成本效益和给药简便性，这些研究结果有助于目前关于采用 TNK 作为治疗中风和 PE 的主要溶栓药物的讨论。
Mortality Outcomes with Tenecteplase Versus Alteplase in the Treatment of Massive Pulmonary Embolism
Background
Pulmonary embolism (PE) leads to many emergency department visits annually. Thrombolytic agents, such as alteplase, are currently recommended for massive PE, but genetically modified tenecteplase (TNK) presents advantages. Limited comparative studies exist between TNK and alteplase in PE treatment.
Objective
The aim of this study was to assess the safety and mortality of TNK compared with alteplase in patients with PE using real-world evidence obtained from a large multicenter registry. Primary outcomes included mortality, intracranial hemorrhage, and blood transfusions.
Methods
This retrospective cohort study used the TriNetX Global Health Research Network. Patients aged 18 years or older with a PE diagnosis (International Classification of Diseases, 10th Revision, Clinical Modification code I26) were included. The following two cohorts were defined: TNK-treated (29 organizations, 266 cases) and alteplase-treated (22,864 cases). Propensity matching controlled for demographic characteristics, anticoagulant use, pre-existing conditions, and vital sign abnormalities associated with PE severity. Patients received TNK or alteplase within 7 days of diagnosis and outcomes were measured at 30 days post thrombolysis.
Results
Two hundred eighty-three patients in each cohort were comparable in demographic characteristics and pre-existing conditions. Mortality rates at 30 days post thrombolysis were similar between TNK and alteplase cohorts (19.4% vs 19.8%; risk ratio 0.982; 95% CI 0.704–1.371). Rates of intracerebral hemorrhages and transfusion were too infrequent to analyze.
Conclusions
This study found TNK to exhibit a similar mortality rate to alteplase in the treatment of PE with hemodynamic instability. The results necessitate prospective evaluation. Given the cost-effectiveness and ease of administration of TNK, these findings contribute to the ongoing discussion about its adoption as a primary thrombolytic agent for stroke and PE.
期刊介绍：
The Journal of Emergency Medicine is an international, peer-reviewed publication featuring original contributions of interest to both the academic and practicing emergency physician. JEM, published monthly, contains research papers and clinical studies as well as articles focusing on the training of emergency physicians and on the practice of emergency medicine. The Journal features the following sections:
• Original Contributions
• Clinical Communications: Pediatric, Adult, OB/GYN
• Selected Topics: Toxicology, Prehospital Care, The Difficult Airway, Aeromedical Emergencies, Disaster Medicine, Cardiology Commentary, Emergency Radiology, Critical Care, Sports Medicine, Wound Care
• Techniques and Procedures
• Technical Tips
• Clinical Laboratory in Emergency Medicine
• Pharmacology in Emergency Medicine
• Case Presentations of the Harvard Emergency Medicine Residency
• Visual Diagnosis in Emergency Medicine
• Medical Classics
• Emergency Forum
• Editorial(s)
• Letters to the Editor
• Education
• Administration of Emergency Medicine
• International Emergency Medicine
• Computers in Emergency Medicine
• Violence: Recognition, Management, and Prevention
• Ethics
• Humanities and Medicine
• American Academy of Emergency Medicine
• AAEM Medical Student Forum
• Book and Other Media Reviews
• Calendar of Events
• Abstracts
• Trauma Reports
• Ultrasound in Emergency Medicine
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