预测儿童哮喘恶化的呼出挥发性有机化合物 (VOC)。

IF 1.4 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Katarzyna Gmachowska, Daniela Podlecka, Radosław Bonikowski, Paweł Majak, Karolina Kapka, Joanna Jerzyńska
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引用次数: 0

摘要

目的通过无创方法--儿童呼出空气中的游离挥发性有机化合物(VOCs)--评估哮喘恶化与气道代谢组学特征之间的可能关系:研究包括 80 名 4-18 岁的哮喘儿童:42名儿童至少在过去 12 个月中有 3 次哮喘加重的 42 名儿童,以及在过去一年中没有加重病史的 38 名儿童。研究访问期间,对每位患者进行了检查,询问了病史(包括有关过敏症和嗜酸性粒细胞血细胞计数的信息),检测了肺活量和呼出一氧化氮分数(FeNO),采集了呼出空气样本以检测是否存在挥发性有机化合物,患者还填写了标准表格--哮喘控制问卷。采用气相色谱-质谱联用技术对挥发性有机化合物进行测量:挥发性有机化合物的检测结果与病史相关。确定了两种气体特征,它们在临床上形成了两个不同的组群(p = 0.085)。第 2 组的特点是儿童支气管哮喘加重的次数较多,肺功能参数较差(1 秒用力呼气容积[FEV1]预测百分比[p = 0.023],FEV1/用力肺活量比[FVC][p = 0.0219])。研究结果与年龄、性别、体重指数、过敏症(屋尘螨过敏)和嗜酸性粒细胞血液计数无关:研究结果表明,一组相对气体可能是预测儿童哮喘加重的有效指标。此外,单一的 FeNO 值不太可能对预测儿童哮喘加重有临床帮助。反映气道上皮代谢和局部微生物群的挥发性有机化合物谱与哮喘的病程有关,因此有必要进行进一步的前瞻性验证研究。Int J Occup Med Environ Health.2024;37(3).
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exhaled volatile organic compounds (VOCs) for prediction of asthma exacerbation in children.

Objectives: To find possible relationship between asthma exacerbation and metabolomic profile of airways, assessed by non-invasive method - free volatile organic compounds (VOCs) in exhaled air in children.

Material and methods: The study included 80 children aged 4-18 years with asthma: 42 children with a min. 3 asthma exacerbations in the past 12 months, and 38 children without a history of exacerbations in the past year. During the study visit, each patient was examined, medical history (including information regarding atopy and eosinophil blood count) was taken, spirometry and fractional exhaled nitric oxide (FeNO) were tested, an exhaled air sample was taken to test for the presence of VOCs, and the patient also completed standardized form - Asthma Control Questionnaire. Volatile organic compounds were measured by combined gas chromatography coupled to mass spectrometry.

Results: The obtained results of VOCs were correlated with the history of the disease. The 2 gas profiles were defined and they formed 2 clinically distinct clusters (p = 0.085). Cluster 2 was characterized for children with a higher number of bronchial asthma exacerbations and worse lung function parameters (predicted percentage forced expiratory volume in 1 s [FEV1] [p = 0.023], FEV1/ forced vital capacity ratio [FVC] [p = 0.0219]). The results were independent of the age, sex, BMI, atopy (house dust mite allergy) and eosinophil blood count.

Conclusions: The study findings suggest that a relative group of gases may be a useful predictor of having asthma exacerbations in children. Additionally, a single FeNO value was unlikely to be clinically useful in predicting asthma exacerbations in children. The VOCs profile reflecting the metabolism of the airway epithelium and local microbiota was associated with the course of asthma, which strongly justifies further prospective validation studies. Int J Occup Med Environ Health. 2024;37(3):351-59.

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来源期刊
CiteScore
3.40
自引率
5.00%
发文量
52
审稿时长
7.5 months
期刊介绍: The Journal is dedicated to present the contemporary research in occupational and environmental health from all over the world. It publishes works concerning: occupational and environmental: medicine, epidemiology, hygiene and toxicology; work physiology and ergonomics, musculoskeletal problems; psychosocial factors at work, work-related mental problems, aging, work ability and return to work; working hours, shift work; reproductive factors and endocrine disruptors; radiation, ionizing and non-ionizing health effects; agricultural hazards; work safety and injury and occupational health service; climate change and its effects on health; omics, genetics and epigenetics in occupational and environmental health; health effects of exposure to nanoparticles and nanotechnology products; human biomarkers in occupational and environmental health, intervention studies, clinical sciences’ achievements with potential to improve occupational and environmental health.
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