George A Wells , Francis Guillemin , Peter A. Merkel , Maarten de Wit , Sarah Mackie , Lyn March , Gunnar Tómasson , Lauren K. King , Sam Michel Cembalo , Shawna Grosskleg , Lara J. Maxwell , Sara Monti , Kaitlin A. Quinn , Beverley J Shea , Peter Tugwell , Dorcas Beaton
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This study presents the methodology and findings of this workshop, exploring the complexities of weighting the individual components of composite outcome measures.</p></div><div><h3>Methods</h3><p>The workshop featured a multifaceted program, beginning with a plenary session that introduced the concept of composite outcomes, shared a patient's journey with rheumatic disease through a narrative, illustrated a composite outcome for Osteoarthritis Flares, and outlined the five domains selected for this composite outcome. A breakout exercise engaged participants in ranking and assigning weights to these domains, followed by group discussions to reach a consensus on weights. The workshop concluded with another plenary session that discussed various weighting approaches, including discrete choice and conjoint analysis from the ANCA-Associated Vasculitis working group, and outlined future directions for research on composite outcome methods.</p></div><div><h3>Results</h3><p>The breakout exercise revealed the challenges in assigning relative importance to different domains, highlighting the variability in participant perspectives. Consensus discussions highlighted the diversity in approaches to weighting, the need for appropriate methods to determine domain weights and the impact of such weights on the interpretation of composite scores.</p></div><div><h3>Conclusion</h3><p>The OMERACT 2023 workshop underscored the significance of a systematic approach to weighting components in composite outcome development. 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The findings contribute to the ongoing discourse on optimizing composite outcome measures in rheumatology and beyond, advocating for a balanced integration of scientific rigour and patient-centeredness in their development.</p></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"69 ","pages":"Article 152503"},"PeriodicalIF":4.6000,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Advancing composite outcome measures: Insights on weighting components from OMERACT 2023\",\"authors\":\"George A Wells , Francis Guillemin , Peter A. Merkel , Maarten de Wit , Sarah Mackie , Lyn March , Gunnar Tómasson , Lauren K. King , Sam Michel Cembalo , Shawna Grosskleg , Lara J. Maxwell , Sara Monti , Kaitlin A. 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引用次数: 0
摘要
目的OMERACT综合工作组在OMERACT 2023会议期间举办了一次研讨会，探讨在制定综合结果时对各组成部分进行加权的复杂性。本研究介绍了该研讨会的方法和研究结果，探讨了对复合结果测量的各个组成部分进行加权的复杂性。方法该研讨会的内容涉及多个方面，首先是全体会议，介绍了复合结果的概念，通过叙述的方式分享了一位风湿病患者的心路历程，展示了骨关节炎发作的复合结果，并概述了为该复合结果选择的五个领域。分组讨论让与会者对这些领域进行排序和权重分配，然后进行小组讨论，就权重达成共识。研讨会最后举行了另一场全体会议，讨论了各种加权方法，包括 ANCA 相关性脉管炎工作组的离散选择和联合分析，并概述了综合结果方法的未来研究方向。共识讨论强调了加权方法的多样性、确定领域权重的适当方法的必要性以及此类权重对综合评分解释的影响。它强调了就领域重要性达成共识的复杂性，以及在此过程中纳入患者研究伙伴观点的作用。未来的研究方向包括完善加权方法、通过 OMERACT 过滤器移动复合结果以及进一步了解其对临床试验的影响。这些研究结果为风湿病学及其他领域正在进行的关于优化复合结果测量的讨论做出了贡献，倡导在开发过程中平衡兼顾科学严谨性和以患者为中心。
Advancing composite outcome measures: Insights on weighting components from OMERACT 2023
Objective
The OMERACT Composite Working Group hosted a workshop at OMERACT 2023 to explore the complexities of weighting components in the development of composite outcomes. This study presents the methodology and findings of this workshop, exploring the complexities of weighting the individual components of composite outcome measures.
Methods
The workshop featured a multifaceted program, beginning with a plenary session that introduced the concept of composite outcomes, shared a patient's journey with rheumatic disease through a narrative, illustrated a composite outcome for Osteoarthritis Flares, and outlined the five domains selected for this composite outcome. A breakout exercise engaged participants in ranking and assigning weights to these domains, followed by group discussions to reach a consensus on weights. The workshop concluded with another plenary session that discussed various weighting approaches, including discrete choice and conjoint analysis from the ANCA-Associated Vasculitis working group, and outlined future directions for research on composite outcome methods.
Results
The breakout exercise revealed the challenges in assigning relative importance to different domains, highlighting the variability in participant perspectives. Consensus discussions highlighted the diversity in approaches to weighting, the need for appropriate methods to determine domain weights and the impact of such weights on the interpretation of composite scores.
Conclusion
The OMERACT 2023 workshop underscored the significance of a systematic approach to weighting components in composite outcome development. It highlighted the complexity of achieving consensus on the importance of domains and the role of incorporating the perspectives of patient research partners in this process. Future research directions include refining weighting methodologies, moving composites through the OMERACT Filter and enhancing understanding of their implications for clinical trials. The findings contribute to the ongoing discourse on optimizing composite outcome measures in rheumatology and beyond, advocating for a balanced integration of scientific rigour and patient-centeredness in their development.
期刊介绍：
Seminars in Arthritis and Rheumatism provides access to the highest-quality clinical, therapeutic and translational research about arthritis, rheumatology and musculoskeletal disorders that affect the joints and connective tissue. Each bimonthly issue includes articles giving you the latest diagnostic criteria, consensus statements, systematic reviews and meta-analyses as well as clinical and translational research studies. Read this journal for the latest groundbreaking research and to gain insights from scientists and clinicians on the management and treatment of musculoskeletal and autoimmune rheumatologic diseases. The journal is of interest to rheumatologists, orthopedic surgeons, internal medicine physicians, immunologists and specialists in bone and mineral metabolism.
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