阴茎癌手术切除边缘的术中冷冻切片检查结果。

IF 2.3 3区 医学 Q3 ONCOLOGY
Karl H. Pang , Mohammad Yunis , Aiman Haider , Alex Freeman , Paul Hadway , Raj Nigam , Rowland Rees , Asif Muneer , Hussain M. Alnajjar
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引用次数: 0

摘要

简介:在阴茎癌保留阴茎手术(PPS)中,对肿瘤切除边缘进行冷冻切片检查(FSE)非常重要。边缘状态将影响切除阴茎或尿道组织的数量。我们的目的是评估 PPS 术中切除边缘 FSE 的效果:我们对2010年至2022年间接受切除边缘FSE检查的阴茎鳞状细胞癌(SCC)患者进行了回顾性分析。将FSE与最终的组织病理学分析进行比较,并计算诊断测试准确性(DTA):敏感性、特异性、阳性预测值(PPV)和阴性预测值(NPV):总共进行了 137 例 FSE。中位(IQR)年龄为 65(53-75)岁。118(86.1%)名患者的 FSE 边缘为阴性,16(11.7%)名患者的 FSE 边缘为阳性,3(2.2%)名患者的结果不明确(非典型细胞)。阴茎 FSE 的敏感性、特异性、PPV、NPV 和诊断准确性分别为 66.7%、100%、100%、93.2% 和 94%。18 名患者因 FSE 阳性或不明确而在同一次病例中接受了进一步的切除手术,其中 12 人(66.7%)达到了阴性边缘。研究的局限性包括研究的回顾性以及缺乏可与之比较的对照组:在本中心进行的术中 FSE 用于评估阴茎 SCC 边缘的敏感性为 66.7%,特异性为 100%。PPS患者应考虑使用FSE,因为它是减少过度治疗的重要而可靠的诊断工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Outcomes of Intraoperative Frozen Section Examination of Surgical Resection Margins of the Penis in Penile Cancer

Introduction

Frozen section examination (FSE) of the tumor resection margins is important during penile-preserving surgery (PPS) in penile cancer. The margin status will impact on how much penile or urethral tissue is excised. We aim to evaluate the outcomes of intraoperative FSE of resection margins in PPS.

Patients and Methods

A retrospective analysis of patients with penile squamous cell carcinoma (SCC) who underwent a FSE of resection margins between 2010 and 2022 was conducted. FSEs were compared with the final histopathological analysis and the Diagnostic Testing Accuracy (DTA): sensitivity, specificity, positive (PPV) and negative predictive values (NPV) were calculated.

Results

Overall, 137 FSE were performed. The median (IQR) age was 65 (53-75) years. 118 (86.1%) patients had negative FSE margins, 16 (11.7%) had positive FSE margins and 3 (2.2%) had equivocal (atypical cells) results. The sensitivity, specificity, PPV, NPV and diagnostic accuracy of penile FSE were 66.7%, 100%, 100%, 93.2% and 94% respectively. 18 patients underwent further resection in the same episode due to a positive or equivocal FSE and 12 (66.7%) achieved negative margins. Limitations include the retrospective nature of the study and lack of control arm to compare with.

Conclusions

Intraoperative FSE performed at our center for the assessment of penile SCC margins is 66.7% sensitive and 100% specific. FSE should be considered in PPS, as it's an essential and a reliable diagnostic tool in minimizing over-treatment.

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来源期刊
Clinical genitourinary cancer
Clinical genitourinary cancer 医学-泌尿学与肾脏学
CiteScore
5.20
自引率
6.20%
发文量
201
审稿时长
54 days
期刊介绍: Clinical Genitourinary Cancer is a peer-reviewed journal that publishes original articles describing various aspects of clinical and translational research in genitourinary cancers. Clinical Genitourinary Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of genitourinary cancers. The main emphasis is on recent scientific developments in all areas related to genitourinary malignancies. Specific areas of interest include clinical research and mechanistic approaches; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; and integration of various approaches.
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