Kanika Jhanji, Zaitoon Shivji, Marion Lazaj, Lysa Boisse Lomax, Gavin P. Winston, Garima Shukla
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引用次数: 0
摘要
目的：很少有出版物报道吸食手工大麻对耐药性癫痫患者整体生活质量的影响。本研究旨在评估成人耐药性癫痫患者吸食手工大麻与生活质量之间的关系，并确定《癫痫生活质量调查表-31》（QOLIE-31）"T 评分 "与不同临床变量之间是否存在关联：这项研究包括加拿大一家三级护理癫痫中心收治的患者，是一项大型研究的一部分。这些患者经非住院癫痫门诊的癫痫专科医生确诊为耐药性癫痫。患者被分为大麻使用者（CAN 组）（n = 25）和非大麻使用者（Non-CAN 组）（n = 21）。在 RedCap® 上收集了有关癫痫和大麻使用详情的数据。使用二元多变量逻辑回归模型分析了所有患者的 QOLIE-31 "T 分数 "与年龄、性别、癫痫持续时间、开始使用的年龄、使用大麻的持续时间和精神病相关合并症之间的关联。此外，还对 CAN 组和非 CAN 组之间问卷的不同 "T 子分数 "进行了比较：结果：CAN 组和非 CAN 组在 "精力和疲劳 "的 T 子得分上存在明显差异（p = 0.004），CAN 组得分更高。然而，在 "总体 T 分 "方面，两组之间没有明显的统计学差异（p = .11）。此外，研究还发现 "总 T 分 "与大麻使用障碍之间存在明显的负相关（p = .032）：本研究为癫痫患者的生活质量与大麻使用之间的关联提供了新数据，可作为今后开展更大规模研究的基础，以更好地评估这种关联。
Quality of life and cannabis use among patients with drug-resistant epilepsy—An observational study from a Canadian tertiary care referral center
Objective
Very few publications have reported the impact of artisanal cannabis use on overall quality of life among people with drug-resistant epilepsy. This study aimed to evaluate the association of artisanal cannabis use among adults with drug-resistant epilepsy with quality of life, and to determine if an association exists between Quality-of-Life in Epilepsy Inventory-31 (QOLIE-31) ‘T scores’ and different clinical variables.
Methods
This study included patients admitted to a Canadian tertiary care epilepsy center as part of a larger study. These patients were confirmed to have drug-resistant epilepsy by an epileptologist at the Ambulatory Epilepsy Clinic. Patients were categorized into cannabis users (CAN group) (n = 25) and Non-cannabis users (Non-CAN group) (n = 21). Data was collected on RedCap® for epilepsy and cannabis use details. These were analyzed for an association using a binary multivariable logistic regression model between QOLIE-31 ‘T scores’ and age, sex, epilepsy duration, age at initiation of use, duration of cannabis use and psychiatric related comorbidity for all patients. Additionally, different ‘T subscores’ of the questionnaire were compared between the CAN group and Non-CAN group.
Results
A statistically significant difference between the CAN group and Non-CAN group for the T subscore ‘energy and fatigue’ (p = .004) was found, with the CAN group scoring higher. However, for the ‘overall T score’ between the two groups there was no statically significant difference (p = .11). Additionally, a significant negative correlation between ‘overall T score’ and cannabis use disorder (p = .032) was found.
Significance
This study provides new data on association of quality of life in epilepsy with cannabis use and can serve as a foundation for larger future studies to better assess this association.
期刊介绍：
Epileptic Disorders is the leading forum where all experts and medical studentswho wish to improve their understanding of epilepsy and related disorders can share practical experiences surrounding diagnosis and care, natural history, and management of seizures.
Epileptic Disorders is the official E-journal of the International League Against Epilepsy for educational communication. As the journal celebrates its 20th anniversary, it will now be available only as an online version. Its mission is to create educational links between epileptologists and other health professionals in clinical practice and scientists or physicians in research-based institutions. This change is accompanied by an increase in the number of issues per year, from 4 to 6, to ensure regular diffusion of recently published material (high quality Review and Seminar in Epileptology papers; Original Research articles or Case reports of educational value; MultiMedia Teaching Material), to serve the global medical community that cares for those affected by epilepsy.
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