Claire M Lanier, Niema B Razavian, Sydney Smith, Ralph B D'Agostino, Ryan T Hughes
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引用次数: 0
摘要
对于体积巨大的弥漫大 B 细胞淋巴瘤(DLBCL),理想的治疗模式仍不确定。我们通过Alliance/CALGB 50303研究了肿瘤体积对仅接受全身治疗的患者的影响。该试验的数据来自美国国立癌症研究所(National Cancer Institute)的NCTN/NCORP数据档案。该研究评估了结节部位的大小,并使用 Cox 比例危险模型估算了无进展生存期(PFS)。分层分析考虑了国际预后指数(IPI)风险评分。在 524 例患者中,155 例接受了治疗前扫描。以7.5厘米为界限,44%的患者被归类为体积过大。无论是连续测量,还是以>5或>7.5厘米为临界值测量,肿块对无进展生存期(PFS)的影响都不大(p = 0.10-p = 0.99)。按治疗组和 IPI 风险组进行的分层分析也不显著。在这项二次分析中,未发现体积与 PFS 之间存在显著关联。
The impact of initial tumor bulk in DLBCL treated with DA-EPOCH-R vs. R-CHOP: a secondary analysis of alliance/CALGB 50303.
The ideal treatment paradigm for bulky diffuse large B-cell lymphoma (DLBCL) remains uncertain. We investigated the impact of tumor bulk in patients treated with systemic therapy alone through Alliance/CALGB 50303. Data from this trial were obtained from the National Cancer Institute's NCTN/NCORP Data Archive. The study assessed the size of nodal sites and estimated progression-free survival (PFS) using Cox proportional hazards models. Stratified analysis factored in International Prognostic Index (IPI) risk scores. Out of 524 patients, 155 had pretreatment scans. Using a 7.5 cm cutoff, 44% were classified as bulky. Bulk did not significantly impact progression-free survival (PFS), whether measured continuously or at thresholds of >5 or >7.5 cm (p = 0.10-p = 0.99). Stratified analyses by treatment group and IPI risk group were also non-significant. In this secondary analysis, a significant association between bulk and PFS was not identified.
期刊介绍:
Leukemia & Lymphoma in its fourth decade continues to provide an international forum for publication of high quality clinical, translational, and basic science research, and original observations relating to all aspects of hematological malignancies. The scope ranges from clinical and clinico-pathological investigations to fundamental research in disease biology, mechanisms of action of novel agents, development of combination chemotherapy, pharmacology and pharmacogenomics as well as ethics and epidemiology. Submissions of unique clinical observations or confirmatory studies are considered and published as Letters to the Editor