针对红斑痤疮多模式发病机制而配制的美容疗法显示出治疗面部红斑和皮肤外观的功效。

IF 1.5 4区 医学 Q3 DERMATOLOGY
Patricia K Farris, Francine H Gerstein, Hilary E Baldwin, Zoe Diana Draelos
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引用次数: 0

摘要

背景:酒糟鼻的治疗很复杂,因为有多种致病因素在起作用,导致包括面部发红在内的各种临床症状和体征:主要目的是评估非处方抗红斑痤疮疗法对红斑痤疮患者的疗效和耐受性:30名红斑痤疮引起的面部红斑患者参加了这项单点、单病程研究。测试方案包括治疗精华液、去红保湿霜和防晒霜。测试产品的配方成分专门针对面部红斑的多因素致病机理。研究人员和受试者在基线、第 4 周和第 8 周对疗效和耐受性进行了自我评估。在所有时间点都对面部红血丝和皮肤水合情况进行了非侵入性评估:研究人员的评分显示,第 4 周和第 8 周的面部红血丝改善率分别为 21% 和 32%。皮肤外观早在 4 周时就得到了改善,而在 8 周时,细纹改善了 15%,光泽度/亮度改善了 37%,触感粗糙度改善了 44%,视觉粗糙度改善了 41%,整体外观改善了 26%。非侵入性评估显示,第 4 周皮肤水合度有 28% 的明显改善,第 8 周面部泛红有 21% 的明显改善。研究人员没有发现任何耐受性问题:红斑痤疮患者通常会求助于非处方产品来减轻面部发红和改善皮肤外观。在这项研究中,一种旨在减轻面部发红的美容护肤品对酒渣鼻患者具有疗效和耐受性。J Drugs Dermatol.2024;23(9):757-763. doi:10.36849/JDD.8460.
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Cosmetic Regimen Formulated to Address the Multi-Modal Pathogenesis of Rosacea Demonstrates Efficacy for Treating Facial Redness and Skin's Appearance.

Background: The treatment of rosacea is complicated as there are multiple pathogenic factors in play resulting in a myriad of clinical signs and symptoms including facial redness.

Objective: The primary objective was to evaluate the efficacy and tolerability of a non-prescription anti-redness regimen in patients with rosacea.

Methods: Thirty subjects with rosacea-induced facial erythema were enrolled in this single site, monadic study. The test regimen consisted of a treatment serum, redness-reducing moisturizer, and sunscreen. The test products are formulated with ingredients curated to address the multifactorial pathogenesis of facial redness. Investigator and subject self-assessment for efficacy and tolerability were performed at baseline, weeks 4 and 8. Non-invasive assessments for facial redness and skin hydration were conducted at all time points.

Results: Investigator grading showed significant improvement in facial redness of 21% at week 4 and 32% at week 8. Skin's appearance improved as early as 4 weeks while at 8 weeks there was statistically significant improvement in fine lines 15%, radiance/brightness 37%, tactile roughness 44%, visual roughness 41%, and 26% in overall appearance. Non-invasive assessments showed statistically significant improvement in skin hydration of 28% at week 4 and facial redness of 21% by week 8. No tolerability issues were identified by the investigator.

Conclusion: Patients with rosacea often turn to over-the-counter products to reduce facial redness and improve skin's appearance. In this study, a cosmetic skincare regimen designed to reduce facial redness demonstrated efficacy and tolerability in subjects with rosacea. J Drugs Dermatol. 2024;23(9):757-763. doi:10.36849/JDD.8460.

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来源期刊
CiteScore
2.20
自引率
13.30%
发文量
289
审稿时长
3-6 weeks
期刊介绍: The Journal of Drugs in Dermatology (JDD) is a peer-reviewed publication indexed with MEDLINE®/PubMed® that was founded by the renowned Dr. Perry Robins MD. Founded in 2002, it offers one of the fastest routes to disseminate dermatologic information and is considered the fastest growing publication in dermatology. We present original articles, award-winning case reports, and timely features pertaining to new methods, techniques, drug therapy, and devices in dermatology that provide readers with peer reviewed content of the utmost quality. Our high standards of content are maintained through a balanced, peer-review process. Articles are reviewed by an International Editorial Board of over 160 renowned experts.
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