Ir 催化的炔诱导酮的化学和对映体选择性加氢反应

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2024-09-04 DOI:10.1039/D4QO01362J

Xuejuan Zheng, Fanping Huang, Jianfei Yu, Qiwei Lang, Ya-Nan Duan, Gen-Qiang Chen and Xumu Zhang

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引用次数: 0

摘要

以 Ir/f-phamidol 为催化剂，在温和条件下实现了 β-炔基 α、β-不饱和酮的不对称氢化反应，并以高产率（高达 99% 收率）和优异的对映选择性（高达 99% ee）获得了相应的手性醇。此外，该反应在 0.1 摩尔%催化负载的克级条件下也表现良好，这表明该反应后续有可能衍生出多种手性烷基醇、药物和天然产物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Ir-catalyzed chemo- and enantioselective hydrogenation of enyne-conjugated ketones†

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Ir-catalyzed chemo- and enantioselective hydrogenation of enyne-conjugated ketones†

The asymmetric hydrogenation of β-alkynyl α,β-unsaturated ketones has been achieved by using Ir/f-phamidol as a catalyst under mild conditions, providing the corresponding chiral alcohols in high yields (up to 99% yield) and with excellent enantioselectivities (up to 99% ee). Moreover, the reaction performed well on a gram scale with 0.1 mol% catalytic loading, indicating the potential use of this protocol in the synthesis of chiral alkyl alcohols, drugs and natural products.

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.