天然低分子量二羰基在动脉粥样硬化和糖尿病发生中的作用

IF 1.9 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Reviews in cardiovascular medicine Pub Date : 2024-08-20 eCollection Date: 2024-08-01 DOI:10.31083/j.rcm2508295

Vadim Z Lankin, Alla K Tikhaze, Mars G Sharapov, Galina G Konovalova

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引用次数: 0

摘要

本综述总结了关于氧化修饰的低密度脂蛋白（LDL）在动脉粥样硬化和糖尿病发生中的作用的长期实验研究数据和文献数据。研究表明，不是 "氧化"（含过氧化脂质）的低密度脂蛋白，而是二羰基修饰的低密度脂蛋白会导致动脉粥样硬化（在清道夫受体的帮助下被培养的巨噬细胞主动捕获）、而且还会导致内皮细胞中氧化低密度脂蛋白受体 1（LOX-1）和烟酰胺腺嘌呤二核苷酸磷酸（NADPH）氧化酶 1（NOX-1）等凝集素基因的表达，从而刺激细胞凋亡和内皮功能障碍。获得的数据使我们能够证明动脉粥样硬化和糖尿病药物治疗的新方法是正确的。

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The Role of Natural Low Molecular Weight Dicarbonyls in Atherogenesis and Diabetogenesis.

This review summarises the data from long-term experimental studies and literature data on the role of oxidatively modified low-density lipoproteins (LDL) in atherogenesis and diabetogenesis. It was shown that not "oxidized" (lipoperoxide-containing) LDL, but dicarbonyl-modified LDL are atherogenic (actively captured by cultured macrophages with the help of scavenger receptors), and also cause expression of lectin like oxidized low density lipoprotein receptor 1 (LOX-1) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 1 (NOX-1) genes in endotheliocytes, which stimulate apoptosis and endothelial dysfunction. The obtained data allowed us to justify new approaches to pharmacotherapy of atherosclerosis and diabetes mellitus.

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来源期刊

Reviews in cardiovascular medicine 医学-心血管系统

CiteScore

2.70

自引率

3.70%

发文量

377

审稿时长

1 months

期刊介绍： RCM is an international, peer-reviewed, open access journal. RCM publishes research articles, review papers and short communications on cardiovascular medicine as well as research on cardiovascular disease. We aim to provide a forum for publishing papers which explore the pathogenesis and promote the progression of cardiac and vascular diseases. We also seek to establish an interdisciplinary platform, focusing on translational issues, to facilitate the advancement of research, clinical treatment and diagnostic procedures. Heart surgery, cardiovascular imaging, risk factors and various clinical cardiac & vascular research will be considered.