{"title":"有氧运动对先天性心脏病术后患者心肺功能的影响:一项 Meta 分析。","authors":"Xiaozhen Guo, Yanran Si, Hairong Liu, Ling Yu","doi":"10.31083/j.rcm2508296","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This meta-analysis aimed to evaluate the impact of aerobic exercise on Peak VO<sub>2</sub> (Oxygen Consumption) in postoperative patients with congenital heart disease (CHD). Besides this, we also tried to discover whether the improvement was influenced by patient ages, modes of supervision, types of exercise, the total dose of exercise, intervention periods, and types of CHD.</p><p><strong>Methods: </strong>Following the Population Intervention Comparison Outcome Study Design (PICOS) principle, a comprehensive search of the PubMed, Web of Science, Embase and Cochrane Library databases was conducted for randomized controlled trials (RCTs) evaluating the intervention effects of aerobic exercise on cardiopulmonary function in postoperative CHD patients until December 2023. This meta-analysis and publication bias tests were conducted using Stata 17.0, and the mean differences (MDs) with 95% confidence intervals (CIs) were used as effect sizes in statistics.</p><p><strong>Results: </strong>A total of 15 RCTs (762 cases) were included in this meta-analysis, with 407 cases in the experimental group and 355 cases in the control group. Meta-analysis showed that aerobic exercise had a positive effect on Peak VO<sub>2</sub> in postoperative CHD patients (MD = 2.14, 95% CI (1.34, 2.94), <i>p</i> <math><mo><</mo></math> 0.00001, I<sup>2</sup> = 36%). The analysis of subgroups showed that intervention effects of aerobic exercise were superior to the control group when patients were <math><mo>></mo></math> 18 years old (MD = 2.53, <i>p</i> <math><mo><</mo></math> 0.00001), <math><mo>≤</mo></math> 18 years old (MD = 1.63, <i>p</i> = 0.01), under supervision (MD = 2.23, <i>p</i> <math><mo><</mo></math> 0.00001), unsupervised (MD = 2.06, <i>p</i> <math><mo><</mo></math> 0.00400), performing aerobic exercise (MD = 1.87, <i>p</i> = 0.0003), performing aerobic exercise combined with resistance training (MD = 2.57, <i>p</i> <math><mo><</mo></math> 0.00010), with a total dose of exercise <math><mo>≥</mo></math> 1440 minutes (MD = 2.45, <i>p</i> <math><mo><</mo></math> 0.00010), with the intervention period of 10-12 weeks (MD = 2.31, <i>p</i> <math><mo><</mo></math> 0.00001), with that <math><mo>></mo></math> 12 weeks (MD = 1.97, <i>p</i> = 0.00300), or with mixed types of CHD (MD = 2.34, <i>p</i> <math><mo><</mo></math> 0.00001).</p><p><strong>Conclusions: </strong>This meta-analysis did not deduct points for limitations, inconsistency, indirectness, imprecision, or publication bias, so the quality of evidence was graded as high. Aerobic exercise has a significantly positive impact on improving Peak VO<sub>2</sub> in postoperative CHD patients. Moreover, it was found that for patients aged 18 and above, supervised aerobic exercise combined with resistance training, implemented for 10-12 weeks with a total dose of exercise <math><mo>≥</mo></math> 1440 minutes, had a better intervention effect on Peak VO<sub>2</sub>. This finding provided evidence-based medicine for the exercise rehabilitation of postoperative CHD patients, and explored the optimal exercise prescription for clinical practice as well.</p><p><strong>Clinical trial registration: </strong>Registered on INPLASY No.202440016 (https://inplasy.com).</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11366990/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effects of Aerobic Exercise on Cardiopulmonary Function in Postoperative Patients with Congenital Heart Disease: A Meta-analysis.\",\"authors\":\"Xiaozhen Guo, Yanran Si, Hairong Liu, Ling Yu\",\"doi\":\"10.31083/j.rcm2508296\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>This meta-analysis aimed to evaluate the impact of aerobic exercise on Peak VO<sub>2</sub> (Oxygen Consumption) in postoperative patients with congenital heart disease (CHD). Besides this, we also tried to discover whether the improvement was influenced by patient ages, modes of supervision, types of exercise, the total dose of exercise, intervention periods, and types of CHD.</p><p><strong>Methods: </strong>Following the Population Intervention Comparison Outcome Study Design (PICOS) principle, a comprehensive search of the PubMed, Web of Science, Embase and Cochrane Library databases was conducted for randomized controlled trials (RCTs) evaluating the intervention effects of aerobic exercise on cardiopulmonary function in postoperative CHD patients until December 2023. This meta-analysis and publication bias tests were conducted using Stata 17.0, and the mean differences (MDs) with 95% confidence intervals (CIs) were used as effect sizes in statistics.</p><p><strong>Results: </strong>A total of 15 RCTs (762 cases) were included in this meta-analysis, with 407 cases in the experimental group and 355 cases in the control group. Meta-analysis showed that aerobic exercise had a positive effect on Peak VO<sub>2</sub> in postoperative CHD patients (MD = 2.14, 95% CI (1.34, 2.94), <i>p</i> <math><mo><</mo></math> 0.00001, I<sup>2</sup> = 36%). The analysis of subgroups showed that intervention effects of aerobic exercise were superior to the control group when patients were <math><mo>></mo></math> 18 years old (MD = 2.53, <i>p</i> <math><mo><</mo></math> 0.00001), <math><mo>≤</mo></math> 18 years old (MD = 1.63, <i>p</i> = 0.01), under supervision (MD = 2.23, <i>p</i> <math><mo><</mo></math> 0.00001), unsupervised (MD = 2.06, <i>p</i> <math><mo><</mo></math> 0.00400), performing aerobic exercise (MD = 1.87, <i>p</i> = 0.0003), performing aerobic exercise combined with resistance training (MD = 2.57, <i>p</i> <math><mo><</mo></math> 0.00010), with a total dose of exercise <math><mo>≥</mo></math> 1440 minutes (MD = 2.45, <i>p</i> <math><mo><</mo></math> 0.00010), with the intervention period of 10-12 weeks (MD = 2.31, <i>p</i> <math><mo><</mo></math> 0.00001), with that <math><mo>></mo></math> 12 weeks (MD = 1.97, <i>p</i> = 0.00300), or with mixed types of CHD (MD = 2.34, <i>p</i> <math><mo><</mo></math> 0.00001).</p><p><strong>Conclusions: </strong>This meta-analysis did not deduct points for limitations, inconsistency, indirectness, imprecision, or publication bias, so the quality of evidence was graded as high. Aerobic exercise has a significantly positive impact on improving Peak VO<sub>2</sub> in postoperative CHD patients. Moreover, it was found that for patients aged 18 and above, supervised aerobic exercise combined with resistance training, implemented for 10-12 weeks with a total dose of exercise <math><mo>≥</mo></math> 1440 minutes, had a better intervention effect on Peak VO<sub>2</sub>. This finding provided evidence-based medicine for the exercise rehabilitation of postoperative CHD patients, and explored the optimal exercise prescription for clinical practice as well.</p><p><strong>Clinical trial registration: </strong>Registered on INPLASY No.202440016 (https://inplasy.com).</p>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2024-08-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11366990/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.31083/j.rcm2508296\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/8/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.31083/j.rcm2508296","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Effects of Aerobic Exercise on Cardiopulmonary Function in Postoperative Patients with Congenital Heart Disease: A Meta-analysis.
Background: This meta-analysis aimed to evaluate the impact of aerobic exercise on Peak VO2 (Oxygen Consumption) in postoperative patients with congenital heart disease (CHD). Besides this, we also tried to discover whether the improvement was influenced by patient ages, modes of supervision, types of exercise, the total dose of exercise, intervention periods, and types of CHD.
Methods: Following the Population Intervention Comparison Outcome Study Design (PICOS) principle, a comprehensive search of the PubMed, Web of Science, Embase and Cochrane Library databases was conducted for randomized controlled trials (RCTs) evaluating the intervention effects of aerobic exercise on cardiopulmonary function in postoperative CHD patients until December 2023. This meta-analysis and publication bias tests were conducted using Stata 17.0, and the mean differences (MDs) with 95% confidence intervals (CIs) were used as effect sizes in statistics.
Results: A total of 15 RCTs (762 cases) were included in this meta-analysis, with 407 cases in the experimental group and 355 cases in the control group. Meta-analysis showed that aerobic exercise had a positive effect on Peak VO2 in postoperative CHD patients (MD = 2.14, 95% CI (1.34, 2.94), p 0.00001, I2 = 36%). The analysis of subgroups showed that intervention effects of aerobic exercise were superior to the control group when patients were 18 years old (MD = 2.53, p 0.00001), 18 years old (MD = 1.63, p = 0.01), under supervision (MD = 2.23, p 0.00001), unsupervised (MD = 2.06, p 0.00400), performing aerobic exercise (MD = 1.87, p = 0.0003), performing aerobic exercise combined with resistance training (MD = 2.57, p 0.00010), with a total dose of exercise 1440 minutes (MD = 2.45, p 0.00010), with the intervention period of 10-12 weeks (MD = 2.31, p 0.00001), with that 12 weeks (MD = 1.97, p = 0.00300), or with mixed types of CHD (MD = 2.34, p 0.00001).
Conclusions: This meta-analysis did not deduct points for limitations, inconsistency, indirectness, imprecision, or publication bias, so the quality of evidence was graded as high. Aerobic exercise has a significantly positive impact on improving Peak VO2 in postoperative CHD patients. Moreover, it was found that for patients aged 18 and above, supervised aerobic exercise combined with resistance training, implemented for 10-12 weeks with a total dose of exercise 1440 minutes, had a better intervention effect on Peak VO2. This finding provided evidence-based medicine for the exercise rehabilitation of postoperative CHD patients, and explored the optimal exercise prescription for clinical practice as well.
Clinical trial registration: Registered on INPLASY No.202440016 (https://inplasy.com).
期刊介绍:
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.