IL-23 在银屑病关节炎中的免疫学作用:潜在的治疗靶点。

IF 3.6 3区 医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Expert Opinion on Biological Therapy Pub Date : 2024-10-01 Epub Date: 2024-09-08 DOI:10.1080/14712598.2024.2401148
Qin-Yi Su, Heng-Yan Gao, Yue-Ru Duan, Jing Luo, Wei-Ze Wang, Xi-Chao Qiao, Sheng-Xiao Zhang
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引用次数: 0

摘要

导言银屑病关节炎(PsA)是一种使人衰弱的慢性疾病,以关节、骨骼、内脏和皮肤的炎症为特征。白细胞介素-23(IL-23)在 PsA 发病机制中的关键作用日益明显。这种促炎细胞因子在 PsA 患者中明显升高,表明它有可能成为治疗靶点。因此,IL-23 抑制剂已成为治疗 PsA 的一线生物疗法:本综述深入探讨了 IL-23 在 PsA 中的细胞和分子水平的免疫致病机制。此外,它还介绍了IL-23抑制剂的最新疗效和安全性。我们在 PubMed 上以下列术语进行了文献检索:IL-23和银屑病关节炎"、"Ustekinumab"、"Guselkumab"、"Risankizumab "和 "Tildrakizumab"。此外,我们还检索了在ClinicalTrials.gov、EudraCT和ICTRP上注册的涉及IL-23抑制剂的临床试验:尽管IL-23抑制剂取得了可喜的成果,但仍存在一些挑战。这些药物的长期效果需要通过前瞻性研究进行进一步调查,而且这些药物在全球范围内的可及性有限,因此亟需关注。此外,还需要不断开展研究,探索 IL-23/IL-23 R 轴的其他潜在药物靶点。开发可靠的生物标志物可大大提高 PsA 患者的早期检测、定制管理策略和个性化治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The immunologic role of IL-23 in psoriatic arthritis: a potential therapeutic target.

Introduction: Psoriatic arthritis (PsA) is a debilitating chronic condition characterized by inflammation of the joints, bones, enthesis, and skin. The pivotal role of interleukin-23 (IL-23) in the pathogenesis of PsA has become increasingly evident. This proinflammatory cytokine is markedly elevated in patients with PsA, suggesting its potential as a therapeutic target. Consequently, IL-23 inhibitors have emerged as promising first-line biologic treatments for PsA.

Areas covered: This review delves into the immunopathogenic mechanisms of IL-23 at the cellular and molecular levels in PsA. Furthermore, it provides the recent efficacy and safety profiles of IL-23 inhibitors. We conducted a literature search in PubMed for the following terms: 'IL-23 and psoriatic arthritis,' 'Ustekinumab,' 'Guselkumab,' 'Risankizumab,' and 'Tildrakizumab.' In addition, we retrieved clinical trials involving IL-23 inhibitors registered in ClinicalTrials.gov, EudraCT, and ICTRP.

Expert opinion: Despite the promising outcomes observed with IL-23 inhibitors, several challenges persist. The long-term effects of these agents require further investigation through prospective studies, and their limited accessibility worldwide necessitates urgent attention. Additionally, ongoing research is warranted to explore other potential drug targets within the IL-23/IL-23 R axis. The development of reliable biomarkers could greatly enhance early detection, tailored management strategies, and personalized treatment approaches for patients with PsA.

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来源期刊
Expert Opinion on Biological Therapy
Expert Opinion on Biological Therapy 医学-生物工程与应用微生物
CiteScore
8.60
自引率
0.00%
发文量
96
审稿时长
3-8 weeks
期刊介绍: Expert Opinion on Biological Therapy (1471-2598; 1744-7682) is a MEDLINE-indexed, international journal publishing peer-reviewed research across all aspects of biological therapy. Each article is structured to incorporate the author’s own expert opinion on the impact of the topic on research and clinical practice and the scope for future development. The audience consists of scientists and managers in the healthcare and biopharmaceutical industries and others closely involved in the development and application of biological therapies for the treatment of human disease. The journal welcomes: Reviews covering therapeutic antibodies and vaccines, peptides and proteins, gene therapies and gene transfer technologies, cell-based therapies and regenerative medicine Drug evaluations reviewing the clinical data on a particular biological agent Original research papers reporting the results of clinical investigations on biological agents and biotherapeutic-based studies with a strong link to clinical practice Comprehensive coverage in each review is complemented by the unique Expert Collection format and includes the following sections: Expert Opinion – a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results; Article Highlights – an executive summary of the author’s most critical points.
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