非磺酰胺细菌 CA 抑制剂。

Q3 Biochemistry, Genetics and Molecular Biology

Enzymes Pub Date : 2024-01-01 Epub Date: 2024-07-20 DOI:10.1016/bs.enz.2024.06.007

Fabrizio Carta

{"title":"非磺酰胺细菌 CA 抑制剂。","authors":"Fabrizio Carta","doi":"10.1016/bs.enz.2024.06.007","DOIUrl":null,"url":null,"abstract":"Non-sulfonamide chemical moieties able to inhibit the bacterial (b) expressed Carbonic Anhydrases (CAs; EC 4.2.1.1) constitute an important alternative to the prototypic modulators discussed in Chapter 6, as give access to large and variegate chemical classes, also of the natural origin. This contribution reports the main classes of compounds profiled in vitro on the bCAs and thus may be worth developing for the validation process of this class of enzymes.","PeriodicalId":39097,"journal":{"name":"Enzymes","volume":"55 ","pages":"193-212"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Non-sulfonamide bacterial CA inhibitors.\",\"authors\":\"Fabrizio Carta\",\"doi\":\"10.1016/bs.enz.2024.06.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Non-sulfonamide chemical moieties able to inhibit the bacterial (b) expressed Carbonic Anhydrases (CAs; EC 4.2.1.1) constitute an important alternative to the prototypic modulators discussed in Chapter 6, as give access to large and variegate chemical classes, also of the natural origin. This contribution reports the main classes of compounds profiled in vitro on the bCAs and thus may be worth developing for the validation process of this class of enzymes.\",\"PeriodicalId\":39097,\"journal\":{\"name\":\"Enzymes\",\"volume\":\"55 \",\"pages\":\"193-212\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Enzymes\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/bs.enz.2024.06.007\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/7/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Enzymes","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/bs.enz.2024.06.007","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/20 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}

引用次数: 0

摘要

能够抑制细菌（b）表达的碳酸酐酶（CAs；EC 4.2.1.1）的非磺酰胺化学分子是第 6 章中讨论的原型调节剂的重要替代品，因为它们提供了大量不同的化学类别（也来自天然来源）。这篇论文报告了体外分析 bCAs 的主要化合物类别，因此可能值得开发用于该类酶的验证过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Non-sulfonamide bacterial CA inhibitors.

Non-sulfonamide chemical moieties able to inhibit the bacterial (b) expressed Carbonic Anhydrases (CAs; EC 4.2.1.1) constitute an important alternative to the prototypic modulators discussed in Chapter 6, as give access to large and variegate chemical classes, also of the natural origin. This contribution reports the main classes of compounds profiled in vitro on the bCAs and thus may be worth developing for the validation process of this class of enzymes.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Enzymes Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

4.30

自引率

0.00%

发文量