为抗击癌症加油：探索支链氨基酸催化对癌症和癌症免疫微环境的影响。

IF 10.8 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Metabolism: clinical and experimental Pub Date : 2024-08-31 DOI:10.1016/j.metabol.2024.156016

Qianquan Ma , Haoyu Li , Zhihao Song , Zhili Deng , Wei Huang , Qing Liu

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引用次数: 0

摘要

支链氨基酸（BCAAs）的代谢对哺乳动物的营养需求至关重要。催化酶的作用是引导全身 BCAAs 氧化，从而导致各种代谢紊乱。重新编程的新陈代谢元素也是恶性肿瘤发生过程的罪魁祸首，有利于在不同癌症周围形成独特的免疫抑制微环境。与 BCAAs 功能失调有关的免疫监视无能是一个新的研究课题。在此，我们将重点研究在癌症进展过程中导致代谢变化和免疫反应失调的 BCAA 催化剂。我们总结了目前有关 BCAA 催化作用的知识，强调了 BCAA 代谢在癌症治疗中的有趣作用。

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Fueling the fight against cancer: Exploring the impact of branched-chain amino acid catalyzation on cancer and cancer immune microenvironment

Metabolism of Branched-chain amino acids (BCAAs) is essential for the nutrient necessities in mammals. Catalytic enzymes serve to direct the whole-body BCAAs oxidation which involve in the development of various metabolic disorders. The reprogrammed metabolic elements are also responsible for malignant oncogenic processes, and favor the formation of distinctive immunosuppressive microenvironment surrounding different cancers. The impotent immune surveillance related to BCAAs dysfunction is a novel topic to investigate. Here we focus on the BCAA catalysts that contribute to metabolic changes and dysregulated immune reactions in cancer progression. We summarize the current knowledge of BCAA catalyzation, highlighting the interesting roles of BCAA metabolism in the treatment of cancers.

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来源期刊

Metabolism: clinical and experimental 医学-内分泌学与代谢

CiteScore

18.90

自引率

3.10%

发文量

310

审稿时长

16 days

期刊介绍： Metabolism upholds research excellence by disseminating high-quality original research, reviews, editorials, and commentaries covering all facets of human metabolism. Consideration for publication in Metabolism extends to studies in humans, animal, and cellular models, with a particular emphasis on work demonstrating strong translational potential. The journal addresses a range of topics, including: - Energy Expenditure and Obesity - Metabolic Syndrome, Prediabetes, and Diabetes - Nutrition, Exercise, and the Environment - Genetics and Genomics, Proteomics, and Metabolomics - Carbohydrate, Lipid, and Protein Metabolism - Endocrinology and Hypertension - Mineral and Bone Metabolism - Cardiovascular Diseases and Malignancies - Inflammation in metabolism and immunometabolism