重新定义康复:ALINA试验对ALK阳性非小细胞肺癌辅助疗法的变革性影响。

IF 5.1 Q1 ONCOLOGY
Lung Cancer: Targets and Therapy Pub Date : 2024-08-28 eCollection Date: 2024-01-01 DOI:10.2147/LCTT.S478054
Zhaohui Liao Arter, Misako Nagasaka
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引用次数: 0

摘要

2024年4月18日,美国食品和药物管理局批准阿来替尼作为肿瘤切除术后无性淋巴瘤激酶(ALK)阳性非小细胞肺癌(NSCLC)患者的辅助治疗药物。ALINA试验结果表明,在辅助治疗中,与传统的铂类化疗相比,阿来替尼能显著提高无病生存率。ALINA试验之所以引人注目,不仅是因为它将ALK酪氨酸激酶抑制剂(TKIs)推进到了辅助治疗阶段,还因为它采用了创新的方法,将TKIs与辅助化疗进行了比较,从而与其他具有里程碑意义的试验区分开来。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Redefining Recovery: The Transformative Impact of the ALINA Trial on Adjuvant Therapy for ALK-Positive Non-Small Cell Lung Cancer.

On April 18, 2024, the Food and Drug Administration approved alectinib as an adjuvant treatment for patients with anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) after tumor resection. This approval was grounded in the outcomes of the ALINA trial, which demonstrated that alectinib significantly enhances disease-free survival compared to traditional platinum-based chemotherapy in the adjuvant setting. The ALINA trial is notable not just for advancing ALK tyrosine kinase inhibitors (TKIs) into the adjuvant setting but also for its innovative approach of comparing them to adjuvant chemotherapy, distinguishing it from other landmark trials.

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来源期刊
CiteScore
8.10
自引率
0.00%
发文量
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审稿时长
16 weeks
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