Jared Schuetter, Angela Minard-Smith, Brandon Hill, Jennifer L Beare, Alexandria Vornholt, Thomas W Burke, Vel Murugan, Anthony K Smith, Thiruppavai Chandrasekaran, Hiba J Shamma, Sarah C Kahaian, Keegan L Fillinger, Mary Anne S Amper, Wan-Sze Cheng, Yongchao Ge, Mary Catherine George, Kristy Guevara, Nora Lovette-Okwara, Avinash Mahajan, Nada Marjanovic, Natalia Mendelev, Vance G Fowler, Micah T McClain, Clare M Miller, Sagie Mofsowitz, Venugopalan D Nair, German Nudelman, Thomas G Evans, Flora Castellino, Irene Ramos, Stas Rirak, Frederique Ruf-Zamojski, Nitish Seenarine, Alessandra Soares-Shanoski, Sindhu Vangeti, Mital Vasoya, Xuechen Yu, Elena Zaslavsky, Lishomwa C Ndhlovu, Michael J Corley, Scott Bowler, Steven G Deeks, Andrew G Letizia, Stuart C Sealfon, Christopher W Woods, Rachel R Spurbeck
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引用次数: 0
摘要
目的：表观基因组影响基因调控和表型对暴露的反应。材料与方法：在此，我们开发并实施了一种机器学习算法--暴露特征发现算法（ESDA），以识别多个表观基因组和转录组数据集中存在的最重要特征，从而生成综合暴露特征（ES）：为七种暴露开发了特征，包括金黄色葡萄球菌、人类免疫缺陷病毒、SARS-CoV-2、甲型流感（H3N2）病毒和炭疽杆菌疫苗接种。ES 在所选检测方法和特征以及预测价值方面存在差异：综合 ES 有可能用于诊断或法医归因。ESDA确定了最显著的特征，有助于为未来的精准健康部署开发诊断面板。
Aim: The epigenome influences gene regulation and phenotypes in response to exposures. Epigenome assessment can determine exposure history aiding in diagnosis.Materials & methods: Here we developed and implemented a machine learning algorithm, the exposure signature discovery algorithm (ESDA), to identify the most important features present in multiple epigenomic and transcriptomic datasets to produce an integrated exposure signature (ES).Results: Signatures were developed for seven exposures including Staphylococcus aureus, human immunodeficiency virus, SARS-CoV-2, influenza A (H3N2) virus and Bacillus anthracis vaccinations. ESs differed in the assays and features selected and predictive value.Conclusion: Integrated ESs can potentially be utilized for diagnosis or forensic attribution. The ESDA identifies the most distinguishing features enabling diagnostic panel development for future precision health deployment.
期刊介绍：
Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community.
Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.
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