调整后的蒙特利尔认知评估与神经心理学评估在诊断术后神经认知障碍方面的比较。

IF 7.5 1区 医学 Q1 ANESTHESIOLOGY
Anaesthesia Pub Date : 2024-09-03 DOI:10.1111/anae.16424
Annerixt Gribnau, Gert J. Geurtsen, Hanna C. Willems, Jeroen Hermanides, Mark L. van Zuylen
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引用次数: 0

摘要

目前用于检测术后神经认知障碍的金标准神经心理学评估耗时过长、成本过高且负担过重,无法在临床实践中使用。蒙特利尔认知评估(MoCA)等简易筛查工具被频繁使用。然而,我们团队之前的研究表明,原始的 MoCA 并不适合检测老年手术患者的术后神经认知障碍[1]。为了提高 MoCA 的准确性,Kessels 等人提出了控制年龄、性别和教育程度的标准[2]。因此,我们的研究旨在比较调整后的MoCA评分在诊断术后神经认知障碍方面的表现。经当地研究伦理委员会批准后,我们在2019年9月至2021年1月期间前瞻性地招募了年龄≥65岁的择期手术患者,涉及任何类型的麻醉或外科手术。荷兰语不流利、术前有认知障碍、严重听力障碍或需要多次麻醉的患者不在研究范围内。原始研究的全部内容见其他文献[1]。术前和术后30-60天同时进行神经心理评估和MoCA,使用不同的版本以尽量减少实践影响。神经心理评估的成绩在与荷兰常模组(https://andi.nl)比较后以 T 分数的形式报告。在神经心理学评估中,认知领域得分≥1 分下降 1-2 SD 表示轻度术后认知障碍,下降≥2 SD 表示重度术后神经认知障碍[3]。在事后分析中,我们根据 Kessels 等人[2]的方法将未经教育校正的原始 MoCA 分数转换为百分位数。轻度术后神经认知障碍的定义是可靠变化指数下降 1-2 SD [4],下降≥ 2 SD 表示重度术后神经认知障碍。通过类内相关系数测量重测可靠性。计算了调整后 MoCA 的灵敏度、特异性和接收者操作特征曲线下面积。我们研究了术前、术后以及术前到术后MoCA与神经心理评估总分和领域得分的相关性。我们将结果转换为z-分数,通过布兰德-阿尔特曼图评估MoCA和神经心理学评估之间的一致性。根据是否存在比例偏差[5],我们选择了普通或回归的一致性限值。共有 73 名患者完成了神经心理评估和 MoCA。基线特征详见在线辅助信息附录 S1。神经心理学评估确定了 14 例(19%)术后神经认知障碍患者,MoCA 诊断了 15 例(21%)认知障碍患者。只有两个病例同时被两种工具确诊(表 1)。神经心理学评估将所有患者归类为轻度术后神经认知障碍,MoCA 诊断出 3 例重度认知障碍患者;然而,其中只有 1 例同时被神经心理学评估诊断为术后神经认知障碍。调整后的MoCA的重测可靠性为中等(在线证明资料附录S2)。接收者操作特征曲线下面积为 0.54(95%CI 0.38-0.70)。术前调整后的MoCA和神经心理评估领域得分之间的相关性为弱至中等(r = 0.12-0.48)。术后相关性很弱到很弱(r = -0.03-0.28),术前与术后MoCA相关性很弱(r = -0.10-0.09)(在线证明资料附录S3)。我们的研究结果表明,尽管对年龄、性别和教育程度进行了调整,但MoCA仍不足以诊断老年择期手术患者术后的神经认知障碍。它不应被用于术后神经认知障碍的临床或研究目的,这与我们之前的研究结果一致[1]。调整后的 MoCA(0.14-0.78)和原始 MoCA(0.21-0.84)的灵敏度和特异性相当。MoCA的不足之处可能是由于术后神经认知障碍患者认知变化的微妙性,因为MoCA仅适用于监测痴呆症患者认知的巨大变化[6]。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Comparison between adjusted Montreal Cognitive Assessment and neuropsychological assessment for diagnosing postoperative neurocognitive disorders

Comparison between adjusted Montreal Cognitive Assessment and neuropsychological assessment for diagnosing postoperative neurocognitive disorders

The current gold standard neuropsychological assessment for detecting postoperative neurocognitive disorders is too time-consuming, costly and burdensome to use in clinical practice. Brief screening instruments, such as the Montreal Cognitive Assessment (MoCA), are used frequently instead. However, previous research by our team suggested that the original MoCA is not suitable to detect postoperative neurocognitive disorders in older adult surgical patients [1]. To improve the accuracy of the MoCA, Kessels et al. presented norms controlling for age, sex and educational level [2]. Accordingly, our study aimed to compare the performance of the adjusted MoCA score in diagnosing postoperative neurocognitive disorder.

We prospectively enrolled patients aged ≥ 65 y scheduled for elective surgery, involving any type of anaesthesia or surgical procedure, from September 2019 to January 2021, after approval by our local research ethics committee. Patients who were not fluent in Dutch, had pre-operative cognitive impairment, severe hearing impairment or needed several procedures under anaesthesia were not studied. The original study is described in full elsewhere [1]. Simultaneous administration of neuropsychological assessment and MoCA occurred pre-operatively and 30–60 days postoperatively, using alternate versions to minimise practice effect. Performance on neuropsychological assessment was reported as T-scores after comparison to a Dutch norm group (https://andi.nl). For neuropsychological assessment, a decline of 1–2 SD on ≥ 1 cognitive domain score indicated mild postoperative cognitive disorder, and ≥ 2 SD decline indicated major postoperative neurocognitive disorder [3]. In the post hoc analysis, we transformed the original, education-uncorrected, MoCA scores to percentiles according to Kessels et al. [2]. Mild postoperative neurocognitive disorder was defined as a reliable change index decrease of 1–2 SD [4] and ≥ 2 SD decline indicated major postoperative neurocognitive disorder. Test–retest reliability was measured by intraclass correlation coefficient. Data were missing completely at random and were imputed.

Sensitivity, specificity and area under the receiver operating characteristic curve of the adjusted MoCA were calculated. We examined pre-operative, postoperative and pre- to postoperative correlations of MoCA and total neuropsychological assessment and domain scores. We transformed the outcome to z-scores to assess agreement between MoCA and neuropsychological assessment by Bland–Altman plots. Ordinary or regression limits of agreement were chosen based on the presence or absence of proportional bias [5].

A total of 73 patients completed neuropsychological assessment and MoCA. Baseline characteristics are detailed in online Supporting Information Appendix S1. Neuropsychological assessment identified 14 (19%) cases of postoperative neurocognitive disorder and MoCA diagnosed 15 (21%) patients with cognitive disorders. Only two cases were diagnosed by both instruments (Table 1). Neuropsychological assessment classified all patients with mild postoperative neurocognitive disorder and MoCA diagnosed three patients with major cognitive disorder; however, only one of these cases was also diagnosed with postoperative neurocognitive disorder by neuropsychological assessment. Test–retest reliability of the adjusted MoCA was moderate (online Supporting Information Appendix S2).

Sensitivity and specificity of the adjusted MoCA were 0.14 (95%CI 0.03–0.38) and 0.78 (95%CI 0.66–0.87), respectively. The area under the receiver operating characteristic curve was 0.54 (95%CI 0.38–0.70). The correlations between pre-operative adjusted MoCA and neuropsychological assessment domain scores were weak to moderate (r = 0.12–0.48). Postoperative correlations were very weak to weak (r = -0.03–0.28) and pre- to postoperative MoCA correlations very weak (r = -0.10–0.09) (online Supporting Information Appendix S3). There was little agreement between pre-operative and postoperative MoCA scores compared with total neuropsychological assessment scores as well as domain scores (Fig. 1, online Supporting Information Appendices S4 and S5).

Our results suggest that the MoCA, despite adjustments for age, sex and educational level, is inadequate for diagnosing postoperative neurocognitive disorders in older adult elective surgical patients. It should not be used for clinical or research purposes for postoperative neurocognitive disorders, aligning with our previous research [1]. Sensitivity and specificity were comparable between adjusted (0.14–0.78) and original MoCA (0.21–0.84), respectively. Possible inadequacy of the MoCA could arise because of the subtlety in cognitive change in patients with postoperative neurocognitive disorders, as MoCA is only tailored for monitoring large cognitive changes in patients with dementia [6]. Additionally, studies showed a limited correlation between MoCA items and corresponding neuropsychological assessment scores, questioning the validity of the MoCA items and their comparability with neuropsychological assessment [7].

A limitation is the lack of a uniform definition for postoperative neurocognitive dysfunction. We chose the recommended approach using cognitive domain scores, but a different definition could possibly alter the results [3]. However, we compared the two diagnosing tools without the need for a definition by measuring agreement and correlations. Furthermore, various tests are used across studies for the gold standard neuropsychological assessment [8]. A strength was that MoCA was administered by trained staff.

We hypothesise that these findings extend to other brief cognitive tests, like the Mini-Mental State Exam, and, therefore, recommend caution in their use for diagnosing postoperative neurocognitive disorders. Collectively, our findings underscore the need for an adequate brief diagnostic tool tailored for postoperative neurocognitive disorder as existing brief instruments, such as the (adjusted) MoCA, seem inadequate.

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来源期刊
Anaesthesia
Anaesthesia 医学-麻醉学
CiteScore
21.20
自引率
9.30%
发文量
300
审稿时长
6 months
期刊介绍: The official journal of the Association of Anaesthetists is Anaesthesia. It is a comprehensive international publication that covers a wide range of topics. The journal focuses on general and regional anaesthesia, as well as intensive care and pain therapy. It includes original articles that have undergone peer review, covering all aspects of these fields, including research on equipment.
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