氧化 NOBINs 生成 α-螺吡咯烷酮。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2024-09-13 Epub Date: 2024-09-03 DOI:10.1021/acs.orglett.4c02499

Yun Yang, Ben Ebel, Iris M Oppel, Frederic W Patureau

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引用次数: 0

摘要

苯酚和 BINOLs 的氧化作用已被充分证明可以产生多种有用的有机支架，但 NOBINs 的氧化作用却鲜为人知。我们在此研究了它们与一些标准化学氧化剂的氧化反应，通过骨架重排得到相应的 α-螺环吡咯烷酮，这是一种稀有且极具价值的杂环核心。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Oxidation of NOBINs Toward α-Spiropyrrolidones.

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Oxidation of NOBINs Toward α-Spiropyrrolidones.

While the oxidation of phenols and BINOLs is well documented to lead to a broad range of useful organic scaffolds, that of NOBINs is far less explored. We investigate herein their oxidation with a number of standard chemical oxidants, leading upon skeletal rearrangement to the corresponding α-spiropyrrolidones, which represent a rare and highly valuable heterocyclic core.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.