探索鞣花酸在胃肠道癌症预防中的潜力：最新进展与未来方向。

IF 3.2 Q2 ONCOLOGY

Oncology and Therapy Pub Date : 2024-12-01 Epub Date: 2024-09-02 DOI:10.1007/s40487-024-00296-1

Abhishek Chauhan, Monika Yadav, Ritu Chauhan, Rupesh Kumar Basniwal, Vinay Mohan Pathak, Anuj Ranjan, Raj Kishor Kapardar, Rajpal Srivastav, Hardeep Singh Tuli, Seema Ramniwas, Darin Mansor Mathkor, Shafiul Haque, Arif Hussain

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引用次数: 0

摘要

胃肠道（GI）癌症是全球关注的重大健康问题，其病因多样，治疗方案有限。鞣花酸（EA）是一种天然多酚类化合物，对各种消化道恶性肿瘤具有良好的抗癌作用。在本文中，我们回顾了最近关于鞣花酸在食管癌、胃癌、结肠直肠癌、胰腺癌和肝癌中的抗癌潜力的研究。在食管癌中，EA 可抑制 N-亚硝基甲基苄胺（NMBA）等致癌物质诱导的 O6-甲基鸟嘌呤（O6-meGua）加合物的形成，从而抑制肿瘤生长。此外，EA 还能抑制 STAT3 信号传导，稳定肿瘤抑制蛋白，具有抗食道癌的潜力。在胃癌中，EA 可调节参与细胞增殖、侵袭和凋亡的多种通路，包括 p53 和 PI3K-Akt 信号通路。它还具有抗炎和抗氧化作用，因此是一种很有希望的胃癌候选疗法。在结直肠癌（CRC）中，EA 可抑制细胞增殖、诱导细胞凋亡、调节 Wnt/β-catenin 和 PI3K/Akt 通路，这表明它在防止 CRC 进展方面具有功效。此外，EA 还能抑制核因子-卡巴 B、诱导细胞凋亡和抑制上皮-间质转化，因此在胰腺癌中大有可为。在肝癌中，EA 具有放射致敏作用，可抑制炎症通路，调节肿瘤微环境，为肝细胞癌的治疗提供了潜在的益处。为了提高对胃肠道癌症的疗效，需要对 EA 在联合疗法中的潜力进行研究，并开发靶向递送系统。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Exploring the Potential of Ellagic Acid in Gastrointestinal Cancer Prevention: Recent Advances and Future Directions.

Gastrointestinal (GI) cancers are a significant global health concern with diverse etiologies and limited treatment options. Ellagic acid (EA), a natural polyphenolic compound, exhibits promising anticancer properties against various GI malignancies. In this article, we have reviewed recent research on the anticancer potential of EA across esophageal, gastric, colorectal, pancreatic, and liver cancers. In esophageal cancer, EA inhibits the formation of O6-methylguanine (O6-meGua) adducts induced by carcinogens like N-nitrosomethylbenzylamine (NMBA), thereby suppressing tumor growth. Additionally, EA inhibits STAT3 signaling and stabilizes tumor suppressor proteins, showing potential as an anti-esophageal cancer agent. In gastric cancer, EA regulates multiple pathways involved in cell proliferation, invasion, and apoptosis, including the p53 and PI3K-Akt signaling pathways. It also demonstrates anti-inflammatory and antioxidant effects, making it a promising therapeutic candidate against gastric cancer. In colorectal cancer (CRC), EA inhibits cell proliferation, induces apoptosis, and modulates the Wnt/β-catenin and PI3K/Akt pathways, suggesting its efficacy in preventing CRC progression. Furthermore, EA has shown promise in pancreatic cancer by inhibiting nuclear factor-kappa B, inducing apoptosis, and suppressing epithelial-mesenchymal transition. In liver cancer, EA exhibits radio-sensitizing effects, inhibits inflammatory pathways, and modulates the tumor microenvironment, offering potential therapeutic benefits against hepatocellular carcinoma. Studies on EA potential in combination therapies and the development of targeted delivery systems are required for enhanced efficacy against gastrointestinal cancers.

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来源期刊

Oncology and Therapy ONCOLOGY-

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 weeks

期刊介绍： Now indexed in PubMed Aims and Scope Oncology and Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality pre-clinical, clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all therapeutic areas. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Oncology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research. Rapid Publication The journal’s rapid publication timelines aim for a peer review decision within 2 weeks of submission. If an article is accepted it will be published online 3-4 weeks from acceptance. These rapid timelines are achieved through the combination of a dedicated in-house editorial team, who closely manage article workflow, and an extensive Editorial and Advisory Board who assist with rapid peer review. This allows the journal to support the rapid dissemination of research, whilst still providing robust peer review. Combined with the journal’s open access model this allows for the rapid and efficient communication of the latest research and reviews, allowing the advancement of clinical therapies. Personal Service The journal’s dedicated in-house editorial team offer a personal “concierge service” meaning that authors will always have a personal point of contact able to update them on the status of their manuscript. The editorial team check all manuscripts to ensure that articles conform to the most recent COPE, GPP and ICMJE publishing guidelines. This supports the publication of ethically sound and transparent research. We also encourage pre-submission enquiries and are always happy to provide a confidential assessment of manuscripts. Digital features and plain language summaries Oncology and Therapy offers a range of additional features designed to increase the visibility, readership and educational value of the journal’s content. 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