Shaoguo Cui, Yibo Tang, Haoming Wan, Rui Wang, Lili Liu
{"title":"[基于分层变换器融合元数据的高级别浆液性卵巢癌轻量级复发预测模型]。","authors":"Shaoguo Cui, Yibo Tang, Haoming Wan, Rui Wang, Lili Liu","doi":"10.7507/1001-5515.202308009","DOIUrl":null,"url":null,"abstract":"<p><p>High-grade serous ovarian cancer has a high degree of malignancy, and at detection, it is prone to infiltration of surrounding soft tissues, as well as metastasis to the peritoneum and lymph nodes, peritoneal seeding, and distant metastasis. Whether recurrence occurs becomes an important reference for surgical planning and treatment methods for this disease. Current recurrence prediction models do not consider the potential pathological relationships between internal tissues of the entire ovary. They use convolutional neural networks to extract local region features for judgment, but the accuracy is low, and the cost is high. To address this issue, this paper proposes a new lightweight deep learning algorithm model for predicting recurrence of high-grade serous ovarian cancer. The model first uses ghost convolution (Ghost Conv) and coordinate attention (CA) to establish ghost counter residual (SCblock) modules to extract local feature information from images. Then, it captures global information and integrates multi-level information through proposed layered fusion Transformer (STblock) modules to enhance interaction between different layers. The Transformer module unfolds the feature map to compute corresponding region blocks, then folds it back to reduce computational cost. Finally, each STblock module fuses deep and shallow layer depth information and incorporates patient's clinical metadata for recurrence prediction. Experimental results show that compared to the mainstream lightweight mobile visual Transformer (MobileViT) network, the proposed slicer visual Transformer (SlicerViT) network improves accuracy, precision, sensitivity, and F1 score, with only 1/6 of the computational cost and half the parameter count. This research confirms that the proposed algorithm model is more accurate and efficient in predicting recurrence of high-grade serous ovarian cancer. In the future, it can serve as an auxiliary diagnostic technique to improve patient survival rates and facilitate the application of the model in embedded devices.</p>","PeriodicalId":39324,"journal":{"name":"生物医学工程学杂志","volume":"41 4","pages":"807-817"},"PeriodicalIF":0.0000,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11366459/pdf/","citationCount":"0","resultStr":"{\"title\":\"[A lightweight recurrence prediction model for high grade serous ovarian cancer based on hierarchical transformer fusion metadata].\",\"authors\":\"Shaoguo Cui, Yibo Tang, Haoming Wan, Rui Wang, Lili Liu\",\"doi\":\"10.7507/1001-5515.202308009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>High-grade serous ovarian cancer has a high degree of malignancy, and at detection, it is prone to infiltration of surrounding soft tissues, as well as metastasis to the peritoneum and lymph nodes, peritoneal seeding, and distant metastasis. Whether recurrence occurs becomes an important reference for surgical planning and treatment methods for this disease. Current recurrence prediction models do not consider the potential pathological relationships between internal tissues of the entire ovary. They use convolutional neural networks to extract local region features for judgment, but the accuracy is low, and the cost is high. To address this issue, this paper proposes a new lightweight deep learning algorithm model for predicting recurrence of high-grade serous ovarian cancer. The model first uses ghost convolution (Ghost Conv) and coordinate attention (CA) to establish ghost counter residual (SCblock) modules to extract local feature information from images. Then, it captures global information and integrates multi-level information through proposed layered fusion Transformer (STblock) modules to enhance interaction between different layers. The Transformer module unfolds the feature map to compute corresponding region blocks, then folds it back to reduce computational cost. Finally, each STblock module fuses deep and shallow layer depth information and incorporates patient's clinical metadata for recurrence prediction. Experimental results show that compared to the mainstream lightweight mobile visual Transformer (MobileViT) network, the proposed slicer visual Transformer (SlicerViT) network improves accuracy, precision, sensitivity, and F1 score, with only 1/6 of the computational cost and half the parameter count. This research confirms that the proposed algorithm model is more accurate and efficient in predicting recurrence of high-grade serous ovarian cancer. In the future, it can serve as an auxiliary diagnostic technique to improve patient survival rates and facilitate the application of the model in embedded devices.</p>\",\"PeriodicalId\":39324,\"journal\":{\"name\":\"生物医学工程学杂志\",\"volume\":\"41 4\",\"pages\":\"807-817\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-08-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11366459/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"生物医学工程学杂志\",\"FirstCategoryId\":\"1087\",\"ListUrlMain\":\"https://doi.org/10.7507/1001-5515.202308009\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"生物医学工程学杂志","FirstCategoryId":"1087","ListUrlMain":"https://doi.org/10.7507/1001-5515.202308009","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
高分化浆液性卵巢癌恶性程度高,发现时易发生周围软组织浸润,以及腹膜和淋巴结转移、腹膜播散和远处转移。是否复发成为该病手术计划和治疗方法的重要参考。目前的复发预测模型没有考虑整个卵巢内部组织之间的潜在病理关系。它们利用卷积神经网络提取局部区域特征进行判断,但准确率低,成本高。针对这一问题,本文提出了一种预测高级别浆液性卵巢癌复发的新型轻量级深度学习算法模型。该模型首先利用幽灵卷积(Ghost Conv)和协调注意力(CA)建立幽灵反残差(SCblock)模块,从图像中提取局部特征信息。然后,它捕捉全局信息,并通过提出的分层融合变换器(STblock)模块整合多层次信息,以增强不同层次之间的互动。变换器模块将特征图展开以计算相应的区域块,然后将其折回以降低计算成本。最后,每个 STblock 模块融合深层和浅层深度信息,并结合患者的临床元数据进行复发预测。实验结果表明,与主流的轻量级移动视觉变换器(MobileViT)网络相比,所提出的切片视觉变换器(SlicerViT)网络提高了准确度、精确度、灵敏度和 F1 分数,而计算成本只有其 1/6 和参数数量的一半。这项研究证实,所提出的算法模型在预测高级别浆液性卵巢癌复发方面更准确、更高效。未来,它可以作为一种辅助诊断技术,提高患者的生存率,并促进该模型在嵌入式设备中的应用。
[A lightweight recurrence prediction model for high grade serous ovarian cancer based on hierarchical transformer fusion metadata].
High-grade serous ovarian cancer has a high degree of malignancy, and at detection, it is prone to infiltration of surrounding soft tissues, as well as metastasis to the peritoneum and lymph nodes, peritoneal seeding, and distant metastasis. Whether recurrence occurs becomes an important reference for surgical planning and treatment methods for this disease. Current recurrence prediction models do not consider the potential pathological relationships between internal tissues of the entire ovary. They use convolutional neural networks to extract local region features for judgment, but the accuracy is low, and the cost is high. To address this issue, this paper proposes a new lightweight deep learning algorithm model for predicting recurrence of high-grade serous ovarian cancer. The model first uses ghost convolution (Ghost Conv) and coordinate attention (CA) to establish ghost counter residual (SCblock) modules to extract local feature information from images. Then, it captures global information and integrates multi-level information through proposed layered fusion Transformer (STblock) modules to enhance interaction between different layers. The Transformer module unfolds the feature map to compute corresponding region blocks, then folds it back to reduce computational cost. Finally, each STblock module fuses deep and shallow layer depth information and incorporates patient's clinical metadata for recurrence prediction. Experimental results show that compared to the mainstream lightweight mobile visual Transformer (MobileViT) network, the proposed slicer visual Transformer (SlicerViT) network improves accuracy, precision, sensitivity, and F1 score, with only 1/6 of the computational cost and half the parameter count. This research confirms that the proposed algorithm model is more accurate and efficient in predicting recurrence of high-grade serous ovarian cancer. In the future, it can serve as an auxiliary diagnostic technique to improve patient survival rates and facilitate the application of the model in embedded devices.