{"title":"[外周血淋巴细胞亚群与前列腺癌的预后有关]。","authors":"Fei Mao, Chao Yang, Lu Ji","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To explore the relationship between peripheral lymphocyte subsets and the survival of PCa patients.</p><p><strong>Methods: </strong>Using the Kaplan-Meier curve and log-rank test, we compared the overall survival (OS) and progression-free survival (PFS) of 100 PCa patients with different levels of lymphocytes. Meanwhile, we investigated the prognostic factors by univariate and multivariate Cox regression analyses, and counted the peripheral lymphocyte subsets by flow cytometry.</p><p><strong>Results: </strong>Both OS and PFS were significantly prolonged in the PCa patients with high levels of lymphocytes (≥747/μl), CD3+T cells (≥528/μl), CD4+T cells (≥315/μl), CD8+T cells (≥226/μl), B cells (≥105/μl) and NK cells (≥168/μl)(P < 0.001). Univariate and multivariate Cox regression analyses indicated that CD4+T cells ≤ 315/μl was an independent factor for the poor prognosis of PCa (HR=12.58, 95% CI: 3.00－52.73).</p><p><strong>Conclusion: </strong>Decreased absolute count of peripheral lymphocyte subsets is associated with the poor prognosis of PCa.</p>","PeriodicalId":24012,"journal":{"name":"中华男科学杂志","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Peripheral blood lymphocyte subsets are associated with the prognosis of prostate cancer].\",\"authors\":\"Fei Mao, Chao Yang, Lu Ji\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To explore the relationship between peripheral lymphocyte subsets and the survival of PCa patients.</p><p><strong>Methods: </strong>Using the Kaplan-Meier curve and log-rank test, we compared the overall survival (OS) and progression-free survival (PFS) of 100 PCa patients with different levels of lymphocytes. Meanwhile, we investigated the prognostic factors by univariate and multivariate Cox regression analyses, and counted the peripheral lymphocyte subsets by flow cytometry.</p><p><strong>Results: </strong>Both OS and PFS were significantly prolonged in the PCa patients with high levels of lymphocytes (≥747/μl), CD3+T cells (≥528/μl), CD4+T cells (≥315/μl), CD8+T cells (≥226/μl), B cells (≥105/μl) and NK cells (≥168/μl)(P < 0.001). Univariate and multivariate Cox regression analyses indicated that CD4+T cells ≤ 315/μl was an independent factor for the poor prognosis of PCa (HR=12.58, 95% CI: 3.00－52.73).</p><p><strong>Conclusion: </strong>Decreased absolute count of peripheral lymphocyte subsets is associated with the poor prognosis of PCa.</p>\",\"PeriodicalId\":24012,\"journal\":{\"name\":\"中华男科学杂志\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华男科学杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华男科学杂志","FirstCategoryId":"3","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
[Peripheral blood lymphocyte subsets are associated with the prognosis of prostate cancer].
Objective: To explore the relationship between peripheral lymphocyte subsets and the survival of PCa patients.
Methods: Using the Kaplan-Meier curve and log-rank test, we compared the overall survival (OS) and progression-free survival (PFS) of 100 PCa patients with different levels of lymphocytes. Meanwhile, we investigated the prognostic factors by univariate and multivariate Cox regression analyses, and counted the peripheral lymphocyte subsets by flow cytometry.
Results: Both OS and PFS were significantly prolonged in the PCa patients with high levels of lymphocytes (≥747/μl), CD3+T cells (≥528/μl), CD4+T cells (≥315/μl), CD8+T cells (≥226/μl), B cells (≥105/μl) and NK cells (≥168/μl)(P < 0.001). Univariate and multivariate Cox regression analyses indicated that CD4+T cells ≤ 315/μl was an independent factor for the poor prognosis of PCa (HR=12.58, 95% CI: 3.00－52.73).
Conclusion: Decreased absolute count of peripheral lymphocyte subsets is associated with the poor prognosis of PCa.
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