罗米波司汀治疗中国慢性原发性免疫性血小板减少症的成本效益分析。

IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL
Yashuang Luo, Wendi Cheng, Yuyan Fu, Haode Wang, Haiyin Wang
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引用次数: 0

摘要

本研究旨在评估在中国成人慢性原发性免疫血小板减少症(cITP)的二线治疗中,罗米波司汀(ROMI)与艾曲波帕(EPAG)相比的成本效用。从中国医疗系统的角度出发,我们采用了一个嵌入决策树的马尔可夫模型来估算ROMI与EPAG的质量调整生命年(QALYs)和成本。该模型由血小板反应驱动,周期为 4 周。QALYs和成本的贴现率均为每年5%。通过匹配调整间接比较(MAIC)获得了ROMI和EPAG的临床数据,利用了ROMI的单个患者数据和EPAG的已公布中国III期试验数据。成本以 2022 美元为单位,包括药物采购成本、监测成本、出血相关成本和不良事件相关成本。进行了确定性和概率敏感性分析。成本效益分析模型显示,使用 ROMI 治疗平均每增加 0.004 QALYs 成本增加 4344.4 美元。单向敏感性分析(OSA)表明,该模型对 EPAG 和 ROMI 的高出血率反应(马尔可夫阶段)最为敏感。概率敏感性分析(PSA)表明,在支付意愿阈值为每 QALY 12039.1 美元(2022 年中国人均 GDP)时,ROMI 在 0.16% 的病例中可能具有成本效益。如果 ROMI 的价格低于或等于 EPAG 的价格,那么 ROMI 作为中国成人 cITP 患者的二线治疗可能具有成本效益。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cost-utility analysis of romiplostim for the treatment of chronic primary immune thrombocytopenia in China.

This study aimed to assess the cost-utility of romiplostim (ROMI) compared to eltrombopag (EPAG) as a second-line treatment for chronic primary immune thrombocytopenia (cITP) in Chinese adults. A decision tree-embedded Markov model with a lifetime horizon was used to estimate the quality-adjusted life years (QALYs) and costs for ROMI versus EPAG from the perspective of the Chinese health care system. The model was driven by platelet response with a 4-week cycle. Both QALYs and costs were discounted 5% per year. Clinical data comparing ROMI and EPAG were obtained by matching-adjusted indirect comparison (MAIC), utilizing individual patient data on ROMI and published Chinese Phase III trial data on EPAG. Costs were reported in 2022 US dollars and included drug acquisition costs, monitoring costs, bleeding-related costs, and costs associated with adverse events. Deterministic and probabilistic sensitivity analyses were performed. The CEA model indicated that treatment with ROMI resulted in an average of $4,344.4 higher costs for 0.004 QALYs. One-way sensitivity analysis (OSA) indicated that the model was most sensitive to the high bleeding rate in response (Markov stage) for EPAG and ROMI. Probabilistic sensitivity analysis (PSA) indicated that ROMI was likely to be cost effective in 0.16% cases at a willingness-to-pay threshold of $12039.1 (China per capita GDP in 2022) per QALY. If the price of ROMI is either lower than or equal to that of EPAG, ROMI could likely be considered cost-effective as a second-line treatment for Chinese adults with cITP.

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来源期刊
Intractable & rare diseases research
Intractable & rare diseases research MEDICINE, GENERAL & INTERNAL-
CiteScore
2.10
自引率
0.00%
发文量
29
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