一位患者因患重症肌无力合并系统性红斑狼疮和甲状腺癌而接受了奥妥木单抗治疗。

IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL

Intractable & rare diseases research Pub Date : 2024-08-31 DOI:10.5582/irdr.2024.01022

Xi Rong, Meijie Qu, Liwei Jiang, Min Liu

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引用次数: 0

摘要

重症肌无力（MG）是一种由B细胞介导的自身免疫性疾病，与神经肌肉接头处突触后膜上的乙酰胆碱受体（AChR）和肌肉特异性受体酪氨酸激酶（MuSK）抗体有关。抗CD20单克隆抗体（如ofatumumab）在MG患者中显示出良好的疾病控制效果。我们报告了一例罕见的病例：一名34岁的女性乙酰胆碱受体阳性重症肌无力（AChR-MG）患者，同时患有系统性红斑狼疮（SLE）和转移性甲状腺癌。

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A patient treated with ofatumumab for myasthenia gravis in conjunction with systemic lupus erythematosus and thyroid carcinoma.

Myasthenia gravis (MG) is an autoimmune disease mediated by B cells and is associated with acetylcholine receptor (AChR) and muscle-specific receptor tyrosine kinase (MuSK) antibodies in the postsynaptic membrane at the neuromuscular junction. Anti-CD20 monoclonal antibodies, such as ofatumumab demonstrated promising disease control in MG patients. We presented the rare case of a 34-year-old female with acetylcholine receptor-positive myasthenia gravis (AChR-MG), concomitant with systemic lupus erythematosus (SLE) and metastatic thyroid carcinoma, who was treated with ofatumumab and exhibited improvements during follow-up.

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来源期刊

Intractable & rare diseases research MEDICINE, GENERAL & INTERNAL-

CiteScore

2.10

自引率

0.00%

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