间充质干细胞在败血症中的作用及其在败血症相关肌病中的治疗潜力(综述)。

IF 5.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
International journal of molecular medicine Pub Date : 2024-11-01 Epub Date: 2024-09-02 DOI:10.3892/ijmm.2024.5416
Dongfang Wang, Ligang Xu, Yukun Liu, Chuntao Wang, Siyuan Qi, Zhanfei Li, Xiangjun Bai, Yiliu Liao, Yuchang Wang
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引用次数: 0

摘要

败血症诱发的肌病(SIM)是危重病人死亡的主要原因之一。SIM主要涉及患者的呼吸肌和骨骼肌,导致肺部感染风险增加、呼吸衰竭加重、机械通气和住院时间延长。SIM 也是危重病人死亡率增加的一个独立风险因素。目前,还没有针对 SIM 的有效治疗方法。不过,间充质干细胞(MSCs)已成为一种很有前景的治疗方法,并已被用于治疗各种临床疾病。大量基础和临床研究支持间充质干细胞在治疗败血症和肌肉相关疾病方面的疗效。本文献综述旨在探讨间充质干细胞与败血症之间的关系,以及间充质干细胞对骨骼肌相关疾病的影响。此外,本综述还讨论了间充质干细胞在治疗脓毒症方面的潜在机制和治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of mesenchymal stem cells in sepsis and their therapeutic potential in sepsis‑associated myopathy (Review).

Sepsis‑induced myopathy (SIM) is one of the leading causes of death in critically ill patients. SIM mainly involves the respiratory and skeletal muscles of patients, resulting in an increased risk of lung infection, aggravated respiratory failure, and prolonged mechanical ventilation and hospital stay. SIM is also an independent risk factor associated with increased mortality in critically ill patients. At present, no effective treatment for SIM has yet been established. However, mesenchymal stem cells (MSCs) have emerged as a promising therapeutic approach and have been utilized in the treatment of various clinical conditions. A significant body of basic and clinical research supports the efficacy of MSCs in managing sepsis and muscle‑related diseases. This literature review aims to explore the relationship between MSCs and sepsis, as well as their impact on skeletal muscle‑associated diseases. Additionally, the present review discusses the potential mechanisms and therapeutic benefits of MSCs in the context of SIM.

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来源期刊
International journal of molecular medicine
International journal of molecular medicine 医学-医学:研究与实验
CiteScore
12.30
自引率
0.00%
发文量
124
审稿时长
3 months
期刊介绍: The main aim of Spandidos Publications is to facilitate scientific communication in a clear, concise and objective manner, while striving to provide prompt publication of original works of high quality. The journals largely concentrate on molecular and experimental medicine, oncology, clinical and experimental cancer treatment and biomedical research. All journals published by Spandidos Publications Ltd. maintain the highest standards of quality, and the members of their Editorial Boards are world-renowned scientists.
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