揭示微/纳米生物材料在治疗幽门螺旋杆菌感染中的潜在作用。

IF 4.2 2区 医学 Q1 INFECTIOUS DISEASES
Misagh Fathi Kisomi, Abbas Yadegar, Tara Shekari, Mohsen Amin, Antoni Llopis-Lorente, Chenguang Liu, Ismaeil Haririan, Hamid Asadzadeh Aghdaei, Mohammad Ali Shokrgozar, Mohammad Reza Zali, Mazda Rad-Malekshahi, Amir Hossein Miri, Michael R Hamblin, Matthias G Wacker
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引用次数: 0

摘要

导言幽门螺杆菌会引起顽固性感染,并导致各种胃部疾病,如消化性溃疡、慢性萎缩性胃炎和胃癌。虽然以抗生素为基础的方法已被广泛应用于幽门螺杆菌的治疗,但抗生素耐药性等一些挑战也日益严重。因此,我们需要更简单但更有效的策略:本综述以通俗易懂的形式介绍了抑制幽门螺杆菌的功能化和非功能化微/纳米生物材料的基本信息和给药途径。随后,全面讨论了一些有前景的生物平台的体外和体内研究,包括用于抑制幽门螺杆菌的金属基生物材料、生物聚合物、小分子糖类和疫苗:专家观点:负载有抗幽门螺杆菌药物的功能化或非功能化微/纳米生物材料可以显示出高效的杀菌活性,同时对宿主胃肠道微生物群没有/只有轻微的负面影响。然而,这种说法需要确凿的数据来证明,如评估抗幽门螺杆菌系统的生物制药参数,以及根除幽门螺杆菌前后宿主胃/肠道微生物群中细菌属的多样性/丰度的测量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unveiling the potential role of micro/nano biomaterials in the treatment of Helicobacter pylori infection.

Introduction: Helicobacter pylori causes stubborn infections and leads to a variety of stomach disorders, such as peptic ulcer, chronic atrophic gastritis, and gastric cancer. Although antibiotic-based approaches have been widely used against H. pylori, some challenges such as antibiotic resistance are increasing in severity. Therefore, simpler but more effective strategies are needed.

Areas covered: In this review, basic information on functionalized and non-functionalized micro/nano biomaterials and routes of administration for H. pylori inhibition are provided in an easy-to-understand format. Afterward, in vitro and in vivo studies of some promising bio-platforms including metal-based biomaterials, biopolymers, small-molecule saccharides, and vaccines for H. pylori inhibition are discussed in a holistic manner.

Expert opinion: Functionalized or non-functionalized micro/nano biomaterials loaded with anti-H. pylori agents can show efficient bactericidal activity with no/slight negative influence on the host gastrointestinal microbiota. However, this claim needs to be substantiated with hard data such as assessment of the biopharmaceutical parameters of anti-H. pylori systems and the measurement of diversity/abundance of bacterial genera in the host gastric/gut microbiota before and after H. pylori eradication.

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来源期刊
CiteScore
11.20
自引率
0.00%
发文量
66
审稿时长
4-8 weeks
期刊介绍: Expert Review of Anti-Infective Therapy (ISSN 1478-7210) provides expert reviews on therapeutics and diagnostics in the treatment of infectious disease. Coverage includes antibiotics, drug resistance, drug therapy, infectious disease medicine, antibacterial, antimicrobial, antifungal and antiviral approaches, and diagnostic tests.
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