Misagh Fathi Kisomi, Abbas Yadegar, Tara Shekari, Mohsen Amin, Antoni Llopis-Lorente, Chenguang Liu, Ismaeil Haririan, Hamid Asadzadeh Aghdaei, Mohammad Ali Shokrgozar, Mohammad Reza Zali, Mazda Rad-Malekshahi, Amir Hossein Miri, Michael R Hamblin, Matthias G Wacker
{"title":"揭示微/纳米生物材料在治疗幽门螺旋杆菌感染中的潜在作用。","authors":"Misagh Fathi Kisomi, Abbas Yadegar, Tara Shekari, Mohsen Amin, Antoni Llopis-Lorente, Chenguang Liu, Ismaeil Haririan, Hamid Asadzadeh Aghdaei, Mohammad Ali Shokrgozar, Mohammad Reza Zali, Mazda Rad-Malekshahi, Amir Hossein Miri, Michael R Hamblin, Matthias G Wacker","doi":"10.1080/14787210.2024.2391910","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong><i>Helicobacter pylori</i> causes stubborn infections and leads to a variety of stomach disorders, such as peptic ulcer, chronic atrophic gastritis, and gastric cancer. Although antibiotic-based approaches have been widely used against <i>H. pylori</i>, some challenges such as antibiotic resistance are increasing in severity. Therefore, simpler but more effective strategies are needed.</p><p><strong>Areas covered: </strong>In this review, basic information on functionalized and non-functionalized micro/nano biomaterials and routes of administration for <i>H. pylori</i> inhibition are provided in an easy-to-understand format. Afterward, <i>in vitro</i> and <i>in vivo</i> studies of some promising bio-platforms including metal-based biomaterials, biopolymers, small-molecule saccharides, and vaccines for <i>H. pylori</i> inhibition are discussed in a holistic manner.</p><p><strong>Expert opinion: </strong>Functionalized or non-functionalized micro/nano biomaterials loaded with anti-<i>H. pylori</i> agents can show efficient bactericidal activity with no/slight negative influence on the host gastrointestinal microbiota. However, this claim needs to be substantiated with hard data such as assessment of the biopharmaceutical parameters of anti-<i>H. pylori</i> systems and the measurement of diversity/abundance of bacterial genera in the host gastric/gut microbiota before and after <i>H. pylori</i> eradication.</p>","PeriodicalId":12213,"journal":{"name":"Expert Review of Anti-infective Therapy","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Unveiling the potential role of micro/nano biomaterials in the treatment of <i>Helicobacter pylori</i> infection.\",\"authors\":\"Misagh Fathi Kisomi, Abbas Yadegar, Tara Shekari, Mohsen Amin, Antoni Llopis-Lorente, Chenguang Liu, Ismaeil Haririan, Hamid Asadzadeh Aghdaei, Mohammad Ali Shokrgozar, Mohammad Reza Zali, Mazda Rad-Malekshahi, Amir Hossein Miri, Michael R Hamblin, Matthias G Wacker\",\"doi\":\"10.1080/14787210.2024.2391910\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong><i>Helicobacter pylori</i> causes stubborn infections and leads to a variety of stomach disorders, such as peptic ulcer, chronic atrophic gastritis, and gastric cancer. 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Unveiling the potential role of micro/nano biomaterials in the treatment of Helicobacter pylori infection.
Introduction: Helicobacter pylori causes stubborn infections and leads to a variety of stomach disorders, such as peptic ulcer, chronic atrophic gastritis, and gastric cancer. Although antibiotic-based approaches have been widely used against H. pylori, some challenges such as antibiotic resistance are increasing in severity. Therefore, simpler but more effective strategies are needed.
Areas covered: In this review, basic information on functionalized and non-functionalized micro/nano biomaterials and routes of administration for H. pylori inhibition are provided in an easy-to-understand format. Afterward, in vitro and in vivo studies of some promising bio-platforms including metal-based biomaterials, biopolymers, small-molecule saccharides, and vaccines for H. pylori inhibition are discussed in a holistic manner.
Expert opinion: Functionalized or non-functionalized micro/nano biomaterials loaded with anti-H. pylori agents can show efficient bactericidal activity with no/slight negative influence on the host gastrointestinal microbiota. However, this claim needs to be substantiated with hard data such as assessment of the biopharmaceutical parameters of anti-H. pylori systems and the measurement of diversity/abundance of bacterial genera in the host gastric/gut microbiota before and after H. pylori eradication.
期刊介绍:
Expert Review of Anti-Infective Therapy (ISSN 1478-7210) provides expert reviews on therapeutics and diagnostics in the treatment of infectious disease. Coverage includes antibiotics, drug resistance, drug therapy, infectious disease medicine, antibacterial, antimicrobial, antifungal and antiviral approaches, and diagnostic tests.